OPRK1, opioid receptor kappa 1, 4986

N. diseases: 156; N. variants: 12
Disease: Neonatal Abstinence Syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027609
Disease: Neonatal Abstinence Syndrome
Neonatal Abstinence Syndrome 		0.020 Biomarker disease BEFREE Buprenorphine, a mu opioid receptor partial agonist and kappa opioid receptor (KOR) antagonist, is an emerging therapeutic agent for maternal opioid dependence in pregnancy and neonatal abstinence syndrome. 29635048 2018
CUI: C0027609
Disease: Neonatal Abstinence Syndrome
Neonatal Abstinence Syndrome 		0.020 GeneticVariation disease BEFREE SNPs in two opioid receptor genes in the infants were associated with worse NAS severity: (1) The PNOC rs732636 A allele (OR=3.8, p=0.004) for treatment with 2 medications and a longer hospital stay (LOS) of 5.8 days (p=0.01), and (2) The OPRK1 rs702764 C allele (OR=4.1, p=0.003) for treatment with 2 medications. 26233486 2015