OPRK1, opioid receptor kappa 1, 4986

N. diseases: 156; N. variants: 12
Disease: Drug Withdrawal Symptoms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0086189
Disease: Drug Withdrawal Symptoms
Drug Withdrawal Symptoms 		0.300 Biomarker phenotype CTD_human Effect of the selective kappa-opioid receptor antagonist JDTic on nicotine antinociception, reward, and withdrawal in the mouse. 20232057 2010
CUI: C0086189
Disease: Drug Withdrawal Symptoms
Drug Withdrawal Symptoms 		0.300 Biomarker phenotype CTD_human Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal. 9463367 1998