OPRK1, opioid receptor kappa 1, 4986

N. diseases: 156; N. variants: 12
Disease: Major Depressive Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.020 Biomarker disease BEFREE Modulation of the opioid system has re-emerged as a potential therapeutic avenue for treating depression, with efficacy of a fixed-dose combination of buprenorphine (BUP), a partial μ-opioid receptor (MOR) agonist and κ-opioid receptor (KOR) antagonist, and samidorphan (SAM), a potent MOR antagonist, as an adjuvant treatment in patients with major depressive disorder (MDD). 30553825 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.020 Biomarker disease BEFREE KOR binding was quantified in vivo by PET imaging with the [<sup>11</sup> C]GR103545 radiotracer in 13 healthy volunteers and 10 participants with current MDD. 29935119 2018