OPRM1, opioid receptor mu 1, 4988

N. diseases: 370; N. variants: 42
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 AlteredExpression disease BEFREE Our results establish the role of hnRNP K and PCPB1 in the translational control of morphine-induced MOR expression in human neuroblastoma (NMB) cells as well as cells stably expressing MOR (NMB1).. 27292014 2017
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 AlteredExpression disease BEFREE Anti-proliferative activity of 8-MOP was evaluated by the BrdU assay in neuroblastoma (SK-N-AS) and metastatic colon cancer (SW620) cells. 28627461 2017
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 Biomarker disease BEFREE The human neuroblastoma cell line SK-N-LO and primary dorsal root ganglia (DRG) cells from mice were used to elucidate mediators of μ-opioid receptor signalling. 24654606 2014
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 AlteredExpression disease BEFREE To investigate the effect of mitragynine after chronic morphine treatment on cyclic AMP (cAMP) level and mRNA expression of mu-opioid receptor (MOR) in human neuroblastoma SK-N-SH cell. 23608241 2013
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 Biomarker disease BEFREE On dissociated neurons and neuroblastoma cells (SH-SY5Y) transfected with NPFF receptors, NPFF acts as a functional antagonist of μ-opioid (MOP) receptors by attenuating the opioid-induced inhibition of calcium conductance. 22375000 2012
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 AlteredExpression disease BEFREE Methamphetamine-mediated modulation of MOR expression in the SH-SY5Y neuroblastoma cell line. 21308796 2011
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 Biomarker disease BEFREE Here, we report fluorescence recovery after photobleaching (FRAP) measurements performed at variable spot radius for human mu opioid (hMOP) receptors on SH-SY5Y neuroblastoma cells in the presence of ligands. 20197280 2010
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 Biomarker disease BEFREE Prolonged (12h) exposure of SH-SY5Y neuroblastoma cells to the mu-opioid receptor (MOPr) agonist [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin (DAMGO) causes homologous desensitization as well as heterologous desensitization of the extracellular signal-regulated kinase 1/2 (ERK 1/2) phosphorylation induced by insulin-like growth factor (IGF)-I. 20643133 2010
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 AlteredExpression disease BEFREE These data are the first to show dual regulation of MOR in neuroblastoma cells. 20615556 2010
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 AlteredExpression disease BEFREE Nandrolone treatment (10-10 M) caused a time-dependent and concentration-dependent downregulation of mu opioid receptor (MOPr) transcripts in SH-SY5Y human neuroblastoma cells. 18596614 2008
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 Biomarker disease BEFREE SV1 and SV2 of hMOR were present in human neuroblastoma NMB cells and human whole brain confirmed by RT-PCR. 16580639 2006
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 Biomarker disease BEFREE Here, we analyse, by fluorescence recovery after photobleaching measurements, the lateral diffusion of fully functional T7-EGFP-hMOP receptors in neuroblastoma SH-SY5Y cells naturally expressing a low level of the wild-type receptor. 16963028 2006
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 Biomarker disease BEFREE In MOP receptor-overexpressing sc2 cells, short-term morphine exposure was found to be much more potent and efficacious in inhibiting forskolin-elicited production of cAMP, and long-term morphine exposure was shown to induce a substantially higher degree of opiate dependence, as reflected by adenylate cyclase sensitization, than it did in wild-type neuroblastoma cells. 15901846 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 AlteredExpression disease BEFREE In this report, we demonstrated that interleukin-6 strongly induces mu-opioid receptor mRNA in the human neuroblastoma cell line SH SY5Y, whereas delta-opioid receptor mRNA levels are not influenced. 15448191 2004
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 Biomarker disease BEFREE Mu-opioid receptor (MuOR) and orphanin FQ/nociceptin receptor (ORL(1)) transcripts were measured after activating this pathway in human neuroblastoma cells. 12106667 2002
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 AlteredExpression disease BEFREE Retinoic acid regulation of mu opioid receptor and c-fos mRNAs and AP-1 DNA binding in SH-SY5Y neuroblastoma cells. 11869806 2002
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 AlteredExpression disease BEFREE Regulation of mu opioid receptor mRNA levels by activation of protein kinase C in human SH-SY5Y neuroblastoma cells. 9366465 1997