OPRM1, opioid receptor mu 1, 4988

N. diseases: 370; N. variants: 42
Disease: Depressed mood ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.030 Biomarker phenotype BEFREE While a variety of prescribed or over-the-counter (OTC) medications are available for pain management, opioid medications, especially those acting on the μ-opioid receptor (μOR) and related pathways, have proven to be the most effective, despite some serious side effects including respiration depression, pruritus, dependence, and constipation. 28935293 2017
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.030 GeneticVariation phenotype BEFREE One gene × gene interaction, 5-HTTLPR variant of the serotonin transporter (SERT/SLC6A4) in combination with μ opioid receptor (OPRM1, rs1799971) was associated with comorbid depression and conduct problems. 26228411 2015
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.030 Biomarker phenotype BEFREE This current study is the first to find an interaction between OPRM1 and life stress that is associated with depression. 24766998 2014