OSBP, oxysterol binding protein, 5007

N. diseases: 29; N. variants: 1
Disease: Enterovirus Infections ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014378
Disease: Enterovirus Infections
Enterovirus Infections 		0.030 Biomarker group BEFREE Therefore, the long-term, compound-induced reduction of OSBP in cells presents a new route to broad spectrum anti- Enterovirus activity, including as a novel route to antiviral prophylactic treatment through small molecule targeting a human host protein. 30576108 2019
CUI: C0014378
Disease: Enterovirus Infections
Enterovirus Infections 		0.030 AlteredExpression group BEFREE The OSW-1-induced reduction of OSBP levels inhibited Enterovirus replication prophylactically in cells. 31271764 2019
CUI: C0014378
Disease: Enterovirus Infections
Enterovirus Infections 		0.030 Biomarker group BEFREE This work supports a two-step resistance model of enterovirus to PI4KB/OSBP inhibitors involving unique recessive epistasis of 3A and 2B and offers insights into a potential evolutionary pathway of enterovirus toward independence from the PI4KB/OSBP pathway. 30919621 2019