OXT, oxytocin/neurophysin I prepropeptide, 5020

N. diseases: 135; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 Biomarker disease PSYGENET Making room for oxytocin in understanding depression. 25025656 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 Biomarker disease PSYGENET Impact of maternal depression across the first 6 years of life on the child's mental health, social engagement, and empathy: The moderating role of oxytocin. 23846912 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 Biomarker disease PSYGENET A moderated mediation model showed that higher levels of depression mediated the inverse relation of high levels of early life adversity to breastfeeding duration, but only in women possessing the CC genotype [effect a' = -3.3401, 95% confidence interval (CI) = -7.9466 to -0.0015] of the OXT SNP and not in women with the AA/AC genotype (a' = -1.2942, ns). 23941164 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 GeneticVariation disease BEFREE A moderated mediation model showed that higher levels of depression mediated the inverse relation of high levels of early life adversity to breastfeeding duration, but only in women possessing the CC genotype [effect a' = -3.3401, 95% confidence interval (CI) = -7.9466 to -0.0015] of the OXT SNP and not in women with the AA/AC genotype (a' = -1.2942, ns). 23941164 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 Biomarker disease PSYGENET Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin. 24025838 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 Biomarker disease PSYGENET Antidepressant-like effect of sildenafil through oxytocin-dependent cyclic AMP response element-binding protein phosphorylation. 22088430 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 AlteredExpression disease BEFREE The objective of this study was to determine, for the first time, the relationship between AVP and OXT gene expression and depressive state in Alzheimer's disease (AD). 19500216 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.310 Biomarker disease PSYGENET Making room for oxytocin in understanding depression. 25025656 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.310 Biomarker disease PSYGENET Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin. 24025838 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.310 Biomarker disease PSYGENET A moderated mediation model showed that higher levels of depression mediated the inverse relation of high levels of early life adversity to breastfeeding duration, but only in women possessing the CC genotype [effect a' = -3.3401, 95% confidence interval (CI) = -7.9466 to -0.0015] of the OXT SNP and not in women with the AA/AC genotype (a' = -1.2942, ns). 23941164 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.310 GeneticVariation disease BEFREE A moderated mediation model showed that higher levels of depression mediated the inverse relation of high levels of early life adversity to breastfeeding duration, but only in women possessing the CC genotype [effect a' = -3.3401, 95% confidence interval (CI) = -7.9466 to -0.0015] of the OXT SNP and not in women with the AA/AC genotype (a' = -1.2942, ns). 23941164 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.310 Biomarker disease PSYGENET Impact of maternal depression across the first 6 years of life on the child's mental health, social engagement, and empathy: The moderating role of oxytocin. 23846912 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.310 Biomarker disease PSYGENET Antidepressant-like effect of sildenafil through oxytocin-dependent cyclic AMP response element-binding protein phosphorylation. 22088430 2012
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.300 Biomarker disease PSYGENET Variant in oxytocin receptor gene is associated with amygdala volume. 21208749 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.300 Biomarker disease PSYGENET Variant in oxytocin receptor gene is associated with amygdala volume. 21208749 2011
CUI: C0032617
Disease: Polyuria
Polyuria 		0.300 Biomarker phenotype CTD_human Oxytocin polyuria and polydipsia is blocked by NaCl administration in food-deprived male rats. 20649851 2010
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.300 Biomarker group PSYGENET No association between oxytocin or prolactin gene variants and childhood-onset mood disorders. 20547007 2010
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.300 Therapeutic group CTD_human Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. 19228979 2009
CUI: C0009421
Disease: Comatose
Comatose 		0.300 Biomarker phenotype CTD_human Oxytocin infusion: acute hyponatraemia, seizures and coma. 19397503 2009
CUI: C0020625
Disease: Hyponatremia
Hyponatremia 		0.300 Biomarker phenotype CTD_human Oxytocin infusion: acute hyponatraemia, seizures and coma. 19397503 2009
CUI: C0022333
Disease: Jacksonian Seizure
Jacksonian Seizure 		0.300 Biomarker disease CTD_human Oxytocin infusion: acute hyponatraemia, seizures and coma. 19397503 2009
CUI: C0036572
Disease: Seizures
Seizures 		0.300 Biomarker phenotype CTD_human Oxytocin infusion: acute hyponatraemia, seizures and coma. 19397503 2009
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.300 Biomarker disease PSYGENET Hypothalamic vasopressin and oxytocin mRNA expression in relation to depressive state in Alzheimer's disease: a difference with major depressive disorder. 19500216 2009
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.300 Biomarker disease PSYGENET Oxytocin receptor polymorphisms and adult attachment style in patients with depression. 19515497 2009
CUI: C0149958
Disease: Complex partial seizures
Complex partial seizures 		0.300 Biomarker disease CTD_human Oxytocin infusion: acute hyponatraemia, seizures and coma. 19397503 2009