OXT, oxytocin/neurophysin I prepropeptide, 5020

N. diseases: 135; N. variants: 5
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs877172
rs877172
Entrez Id: 5020;101929098
Gene Symbol: OXT;LOC101929098
OXT;LOC101929098
CUI: C2985280
Disease:
Blood Protein Measurement
T 0.700 GeneticVariation GWASCAT Co-regulatory networks of human serum proteins link genetics to disease. 30072576 2018
dbSNP: rs2740210
rs2740210
Entrez Id: 5020;101929098
Gene Symbol: OXT;LOC101929098
OXT;LOC101929098
CUI: C0003469
Disease:
Anxiety Disorders
0.010 GeneticVariation BEFREE If the child was carrier of rs2740210 CA/AA polymorphism, exposure to maternal verbally aggressive behavior (10.6%) was positively associated with general anxiety at age 5-6 and emotional symptoms at age 11-12 (p for interaction = 0.011 and p = 0.015, respectively). 31065789 2019
dbSNP: rs2740210
rs2740210
Entrez Id: 5020;101929098
Gene Symbol: OXT;LOC101929098
OXT;LOC101929098
CUI: C0003467
Disease:
Anxiety
0.010 GeneticVariation BEFREE If the child was carrier of rs2740210 CA/AA polymorphism, exposure to maternal verbally aggressive behavior (10.6%) was positively associated with general anxiety at age 5-6 and emotional symptoms at age 11-12 (p for interaction = 0.011 and p = 0.015, respectively). 31065789 2019
dbSNP: rs2770378
rs2770378
Entrez Id: 5020;101929098
Gene Symbol: OXT;LOC101929098
OXT;LOC101929098
CUI: C1842981
Disease:
NEUROTICISM
0.010 GeneticVariation BEFREE Results indicated that the OXT-Neurophysin I rs2770378 was related to extraversion, agreeableness, and neuroticism. 29501452 2019
dbSNP: rs4813625
rs4813625
Entrez Id: 5020;101929098
Gene Symbol: OXT;LOC101929098
OXT;LOC101929098
CUI: C0424166
Disease:
Social Anxiety
0.010 GeneticVariation BEFREE The findings may be interpreted from the perspective of the social salience hypothesis of oxytocin, with rs4813625 affecting social anxiety levels along a perceived unsafe-safe social context dimension. 28606214 2018
dbSNP: rs6133010
rs6133010
Entrez Id: 5020;101929098
Gene Symbol: OXT;LOC101929098
OXT;LOC101929098
CUI: C0001973
Disease:
Alcoholic Intoxication, Chronic
0.010 GeneticVariation BEFREE The present study found that rs6133010 in the OXT gene is associated with AD in the northern Chinese Han population. 27818356 2017
dbSNP: rs2740210
rs2740210
Entrez Id: 5020;101929098
Gene Symbol: OXT;LOC101929098
OXT;LOC101929098
CUI: C0011581
Disease:
Depressive disorder
0.010 GeneticVariation BEFREE In our primary sample, polymorphisms in OXT rs2740210, but not the other SNPs, interacted with early life adversity to predict variation in breastfeeding duration (overall F8,125  = 2.361, P = 0.021; interaction effect b = -8.12, t = -2.3, P = 0.023) and depression (overall F8,118  = 5.751, P ≤ 0.001; interaction effect b = 6.06, t = 3.13, P = 0.002). 23941164 2013
dbSNP: rs2740210
rs2740210
Entrez Id: 5020;101929098
Gene Symbol: OXT;LOC101929098
OXT;LOC101929098
CUI: C0011570
Disease:
Mental Depression
0.010 GeneticVariation BEFREE In our primary sample, polymorphisms in OXT rs2740210, but not the other SNPs, interacted with early life adversity to predict variation in breastfeeding duration (overall F8,125  = 2.361, P = 0.021; interaction effect b = -8.12, t = -2.3, P = 0.023) and depression (overall F8,118  = 5.751, P ≤ 0.001; interaction effect b = 6.06, t = 3.13, P = 0.002). 23941164 2013
dbSNP: rs2740210
rs2740210
Entrez Id: 5020;101929098
Gene Symbol: OXT;LOC101929098
OXT;LOC101929098
CUI: C0221074
Disease:
Depression, Postpartum
0.010 GeneticVariation BEFREE Genetic variation in oxytocin rs2740210 and early adversity associated with postpartum depression and breastfeeding duration. 23941164 2013
dbSNP: rs2740210
rs2740210
Entrez Id: 5020;101929098
Gene Symbol: OXT;LOC101929098
OXT;LOC101929098
CUI: C0344315
Disease:
Depressed mood
0.010 GeneticVariation BEFREE In our primary sample, polymorphisms in OXT rs2740210, but not the other SNPs, interacted with early life adversity to predict variation in breastfeeding duration (overall F8,125  = 2.361, P = 0.021; interaction effect b = -8.12, t = -2.3, P = 0.023) and depression (overall F8,118  = 5.751, P ≤ 0.001; interaction effect b = 6.06, t = 3.13, P = 0.002). 23941164 2013
dbSNP: rs2740210
rs2740210
Entrez Id: 5020;101929098
Gene Symbol: OXT;LOC101929098
OXT;LOC101929098
CUI: C0036341
Disease:
Schizophrenia
0.010 GeneticVariation BEFREE Using n = 406 individuals diagnosed with schizophrenia according to DSM-IV and n = 406 healthy controls matched for age and gender in a case-control design, two single nucleotide polymorphisms (SNPs) within the OXT gene (rs2740204, rs2740210) and four SNPs within the OXTR gene (rs53576, rs237880, rs237885, rs237902) that were previously investigated in other studies were genotyped. 22651577 2013