|
Epilepsy
|
0.100 |
Biomarker
|
disease |
BEFREE |
We present evidence that P2X7 may have a detrimental or beneficial role in the nervous system, in the context of neurological pathologies: epilepsy, Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, age-related macular degeneration and cerebral artery occlusion.
|
31551714 |
2019 |
|
Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present study was to assess the expression of P2X7R, glutamate (GLU) and glial fibrillary acidic protein (GFAP) in the temporal neocortex and hippocampus of rats with lithium‑pilocarpine‑induced epilepsy as well as in patients with intractable TLE.
|
31059094 |
2019 |
|
Epilepsy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The electrophysiological and biochemical analysis of present study suggest that P2X7Rs and its interaction with T-type calcium ion channels play an important role in the experimental model of epilepsy.
|
30695710 |
2019 |
|
Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recently, we showed that neocortical nerve terminals from patients with epilepsy express higher amounts of the non-desensitizing ionotropic P2X7 receptor.
|
29154812 |
2018 |
|
Epilepsy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Preclinical studies revealed that P2X7 receptor antagonists have anticonvulsant properties in some models of epilepsy.
|
28702712 |
2017 |
|
Epilepsy
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest P2X7R activation plays a critical role in epileptogenesis via regulation of neuroinflammation and blocking P2X7R may be a novel therapeutic strategy for epilepsy.
|
28856625 |
2017 |
|
Epilepsy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The ATP-gated purinergic P2X7 receptor (P2X7) has been proposed as a novel drug target for a host of neurological conditions, including epilepsy.
|
28210205 |
2017 |
|
Epilepsy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The P2X7 receptor (P2X7R) for ATP is a therapeutic target for pathophysiological states including inflammation, pain management and epilepsy.
|
28389651 |
2017 |
|
Epilepsy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, our data highlights the potential of P2X7R as a therapeutic target for the adjunct treatment of epilepsy.
|
28707031 |
2017 |
|
Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Changes in P2X7R expression have been reported in both experimental models and in epilepsy patients but the mechanism(s) controlling P2X7R levels remain incompletely understood.
|
27840225 |
2017 |
|
Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using a reporter mouse in which green fluorescent protein is induced in response to the transcription of P2rx7, we show that expression of the receptor is selectively increased in CA1 pyramidal and dentate granule neurons, as well as in microglia in mice that developed epilepsy after intra-amygdala kainic acid-induced status epilepticus.
|
27251615 |
2016 |