P2RX7, purinergic receptor P2X 7, 5027

N. diseases: 337; N. variants: 23
Disease: Unipolar Depression ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.080 GeneticVariation disease BEFREE Comprehensive investigation of the P2X7R Gln460Arg missense mutation (rs2230912), which has been associated with major depression and bipolar disorder, has substantially contributed to validate P2X7R as a potential genetic risk factor. 30093269 2018
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.080 GeneticVariation disease BEFREE P2RX7 polymorphisms Gln460Arg and His155Tyr are not associated with major depressive disorder or remission after SSRI or ECT. 21335057 2011
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.080 GeneticVariation disease BEFREE The single nucleotide polymorphisms FKBP5:rs1360780, BDNF:rs6265 (Val66Met), P2RX7:2230912 (Gln460Arg) and CACNA1C:rs1006737 were genotyped in DNA from 457 depression cases (major depression, dysthymia, and mixed anxiety depression) and 2286 healthy controls with no symptom of psychopathology. 20226536 2010
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.080 GeneticVariation disease BEFREE A non-synonymous single nucleotide polymorphism, rs2230912 (P2RX7-E13A, G allele) and a microsatellite marker NBG6 were both previously found to be associated with bipolar disorder (P=0.00071 and 0.008, respectively). rs2230912 has also been found to show association with unipolar depression. 18268501 2009
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.080 GeneticVariation disease BEFREE Variation in P2RX7 candidate gene (rs2230912) is not associated with bipolar I disorder and unipolar major depression in four European samples. 19330776 2009
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.080 GeneticVariation disease BEFREE Recently, the immune-related gene encoding purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7) has been genetically associated with major depressive disorder and bipolar disorder. 17963976 2007
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.080 Biomarker disease BEFREE Recent linkage studies have shown that the P2X7 gene is associated with major depression and bipolar disorder. 17558618 2007
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.080 Biomarker disease BEFREE P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder. 16822851 2006