Based on the crosstalk between microglia and brain microenvironment, a reactive oxygen species (ROS)-responsive polymeric micelle system (Ab-PEG-LysB/curcumin (APLB/CUR)) is reported to normalize the oxidative and inflammatory microenvironment and reeducate microglia from an early phase of AD.
In this study, we used protoporphyrin IX (PX)-modified oxidized mesoporous carbon nanospheres (OMCN) (PX@OMCN@PEG(OP)@RVGs) as a novel AD multifunctional nanodrug having multiple targets.
MoCA scores were negatively correlated with GDS-30 both at the subject level (correlation coefficient r<sub>3</sub>=-0.68, χ<sup>2</sup>=19.26, P<0.001) and time point level (r<sub>2</sub>=-0.35, χ<sup>2</sup>=35.68, P<0.001) in patients with AD.
Our previous study indicated that PEG-PEI/siROCK2 could effectively suppress ROCK2 mRNA expression and showed a promising prospect for the treatment of Alzheimer's disease.