|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cigarette smoke caused NADPH oxidase (NOX) 2 expression in diabetic aorta and enhanced diabetes-induced NOX4 expression in aorta.
|
31759066 |
2020 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Diabetes elevates NOX4 expression in podocytes and mesangial cells, which was shown to damage glomeruli leading to podocyte loss, mesangial cell hypertrophy and matrix accumulation.
|
29931336 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Unmasking the interplay between mTOR and Nox4: novel insights into the mechanism connecting diabetes and cancer.
|
31661292 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
NOX4 plays a key role in other adenocarcinomas and has been implicated in the pathogenesis of diabetes and obesity, which are important risk factors for endometrial cancer.
|
30813866 |
2019 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Glycine mitigates renal oxidative stress by suppressing Nox4 expression in rats with streptozotocin-induced diabetes.
|
30196019 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Oxymatrine ameliorates diabetes-induced aortic endothelial dysfunction via the regulation of eNOS and NOX4.
|
30456880 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
ASE reduced oxidative damage markers (TBARS, carbonyl levels and 8-isoprostane) in D and DH associated with a decrease in Nox 4 and p47 subunit expression and increase in antioxidant enzyme activity in both groups (SOD, catalase and GPx).
|
28105508 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In contrast, activation of NOX4 appears to promote physiologic angiogenesis mainly by protecting the vasculature during ischemia, hypoxia and inflammation and by restoring vascularization, except in models of oxygen-induced retinopathy and diabetes where NOX4 activation leads to pathologic angiogenesis.
|
28587189 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
As dose-dependent and tissue-specific effects of the dual NOX1/4 inhibitor GKT137831 were observed, it is critical to define in further studies the relative balance of inhibiting NOX4 vs NOX1 in the micro- and macrovasculature in diabetes.
|
28160092 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
NADPH oxidase 4 (NOX4), a source of cellular superoxide anions, has multiple biological functions that may be of importance in inflammation and in the pathogenesis of human metabolic diseases, including diabetes.
|
27455510 |
2016 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our previous study suggests that upregulation of Nox4 in retinal endothelial cells contributes to retinal vascular leakage in diabetes.
|
25866826 |
2015 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, these results identify Nox4 as a key source of ROS responsible for kidney injury in diabetes and provide proof of principle for an innovative small molecule approach to treat and/or prevent chronic kidney failure.
|
24511132 |
2014 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes.
|
20861022 |
2010 |