SERPINE1, serpin family E member 1, 5054

N. diseases: 770; N. variants: 23
Disease: Fibrinolytic Defect ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1851184
Disease: Fibrinolytic Defect
Fibrinolytic Defect 		0.020 AlteredExpression disease BEFREE Despite any preconceptions, examination for a fibrinolytic defect ultimately demonstrated a PAI-1 antigen level of 11.4 ng/mL (4.0-43 ng/mL) and PAI-1 activity less than 5 AU/mL (5-37 AU/mL) and clinically supported a diagnosis of a hereditary, qualitative PAI-1 defect. 15247991 2004
CUI: C1851184
Disease: Fibrinolytic Defect
Fibrinolytic Defect 		0.020 Biomarker disease BEFREE Locally increased amplification of plasminogen activator inhibitor-1 (PAI-1) is largely responsible for this fibrinolytic defect. 12682443 2003