|
Acute Lung Injury
|
0.200 |
Biomarker
|
disease |
RGD |
Genome‑wide analysis of DNA methylation in rat lungs with lipopolysaccharide‑induced acute lung injury.
|
23546543 |
2013 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of PAK1 alleviates cerulein-induced acute pancreatitis via p38 and NF-κB pathways.
|
30718368 |
2019 |
|
Adenocarcinoma
|
0.030 |
GeneticVariation
|
group |
BEFREE |
The effect of IPA-3 (PAK1 inhibitor) plus auranofin (PKCι inhibitor) combination was evaluated by cell viability assay, colony formation and western blotting assay, using three types of NSCLC cell lines: EGFR or KRAS mutant adenocarcinoma and squamous cell carcinoma with PAK1 amplification.
|
31660987 |
2019 |
|
Adenocarcinoma
|
0.030 |
AlteredExpression
|
group |
BEFREE |
PAK1 expression could serve as a prognostic predictor that holds therapeutic promise for GEJ adenocarcinoma.
|
24236193 |
2013 |
|
Adenocarcinoma
|
0.030 |
Biomarker
|
group |
BEFREE |
In this study, we sought to analyze the prognostic value of p21-activated kinase 1 (PAK1), p21-activated kinase 4 (PAK4), human equilibrative nucleoside transporter 1 (hENT1), and thymidylate synthase (TS) in surgically resected pancreatic ductal adenocarcinomas.
|
28556956 |
2017 |
|
Adenocarcinoma of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that Pak1 expression levels are reduced during cancer-induced cachexia in the Tibialis Anterior muscles of colon adenocarcinoma C26-bearing mice and in vitro during dexamethasone-induced myotube atrophy.
|
29781585 |
2018 |
|
Adenocarcinoma of large intestine
|
0.010 |
Biomarker
|
disease |
BEFREE |
The potential role of the NEK6, AURKA, AURKB, and PAK1 genes in adenomatous colorectal polyps and colorectal adenocarcinoma.
|
26423403 |
2016 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
Forty-six tumor tissues from patients with lung adenocarcinoma who received TKI therapy were collected to evaluate PAK1 and E-cadherin mRNA expressions by real-time PCR.
|
27178741 |
2016 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
In summary, a total of nine genes that may play important roles in the development of LUAD were identified, and two (PAK1 and FGFR2) of them can be served as prognostic biomarkers for LUAD patients.
|
30370535 |
2019 |
|
Adenocarcinoma of the gastroesophageal junction
|
0.020 |
Biomarker
|
disease |
BEFREE |
Prognostic importance and therapeutic implications of PAK1, a drugable protein kinase, in gastroesophageal junction adenocarcinoma.
|
24236193 |
2013 |
|
Adenocarcinoma of the gastroesophageal junction
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this study, bioinformatics and pathological analysis identified that p21 protein-activated kinase 1 (PAK1) is associated with lymph nodal metastasis of GEJA.
|
25159681 |
2015 |
|
Adenoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Our immunohistochemistry showed that PAK1 expression was increased with colorectal cancer (CRC) progression through the adenoma to carcinoma sequence.
|
22252525 |
2012 |
|
Adult Fibrosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results identify a novel mechano-sensitive response in human fibrosarcoma that utilizes PAK1 as a signaling player positioned downstream of integrin β3.
|
31781560 |
2019 |
|
Adult Glioblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Nudt21 regulates the alternative polyadenylation of Pak1 and is predictive in the prognosis of glioblastoma patients.
|
30705404 |
2019 |
|
Adult Glioblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Thus, neurofibromin-deficient glioblastoma and mouse fibroblasts are enriched in Rac1-GTP, p-Pak1, p-LIMK1 and p-cofilin, with all proteins exhibiting decreased expression upon expression of NF1(1-1163) polypeptide.
|
19666124 |
2009 |
|
Adult Glioblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
We then down-regulated Pak1 by using small interfering RNA to knock down Pak1 in two glioblastoma cell lines to determine whether Pak1 contributed to cell viability and invasion.
|
18006760 |
2007 |
|
Adult Myelodysplastic Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome.
|
26170031 |
2015 |
|
Adult Rhabdomyosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The infectious entry of HEV71 into rhabdomyosarcoma cells was shown to be significantly inhibited by siRNAs targeting genes associated with clathrin-mediated endocytosis (CME) that include AP2A1, ARRB1, CLTC, CLTCL1, SYNJ1, ARPC5, PAK1, ROCK1, and WASF1.
|
20956521 |
2011 |
|
Alopecia
|
0.010 |
Biomarker
|
disease |
BEFREE |
PAK1 (p21-activated kinase 1) is an emerging target for the treatment of hair loss (alopecia) and cancer; therefore, the search for PAK1 blockers to treat these PAK1-dependent disorders has received much attention.
|
28098826 |
2017 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Furthermore, loss of Pak1 has been associated with the progression of neurodegenerative disorders, particularly Alzheimer's disease, while up-regulation and de-regulation may be responsible for oncogenic transformation of support cells within the CNS, especially astrocyte progenitors.
|
18649038 |
2008 |
|
Alzheimer's Disease
|
0.020 |
GeneticVariation
|
disease |
LHGDN |
p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis.
|
18347024 |
2008 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In this study, we analyzed the expression of Pak1 in human pancreatic cancer tissues and found that Pak1 levels are significantly upregulated in PDAC samples as compared with adjacent normals.
|
24561527 |
2015 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.020 |
Biomarker
|
disease |
BEFREE |
However, efforts to target several components of this network have resulted in only a handful of drugs demonstrating any survival benefit in solid tumors; despite promising pre-clinical results. p-21 activated kinase 4 (PAK4) is a gene that is recurrently amplified or overexpressed in PDAC and both PAK4 and related family member PAK1, have been linked to aberrant RAS activity, a common feature in pancreatic cancer.
|
27845911 |
2017 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we report the effect of Pak1 on atherogenesis using atherosclerosis-prone apolipoprotein E-deficient (ApoE(-/-)) mice as a model.
|
26104863 |
2015 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, this study demonstrates that inhibition of PAK1 attenuates the cardinal features of asthma through suppressing the DC trafficking from lung to the MLN, and that interfere with DC trafficking by a PAK1 inhibitor thus holds great promise for the therapeutic intervention of allergic diseases.
|
29906467 |
2018 |