PAPPA, pappalysin 1, 5069

N. diseases: 125; N. variants: 12
Disease: ovarian neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.040 Biomarker disease BEFREE This study further tests the efficacy of PAPP-A inhibition with a monoclonal antibody inhibitor (mAb-PA) in ovarian cancer (OC) platinum-resistant patient-derived xenograft (PDX) models. 31751381 2019
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.040 Biomarker disease BEFREE Together, these data indicate PAPP-A as a potential palliative and adjunct therapeutic target for women with ovarian cancer. 25695953 2015
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.040 Biomarker disease BEFREE In experimental animals, PAPP-A accelerates ovarian tumor growth by this mechanism. 26336825 2015
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.040 AlteredExpression disease BEFREE IGF-I, IGF-II, IGFBP-4, and PAPP-A gene expression was determined in a panel of GCT and compared to the levels in normal ovary and in epithelial ovarian tumors. 17177834 2007