PARN, poly(A)-specific ribonuclease, 5073

N. diseases: 144; N. variants: 14
Disease: Central neuroblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.060 Biomarker disease BEFREE Thirteen other TGFβ regulators (Chordin, Chordin-like 1, Chordin-like 2, Differential screening-selected gene aberrative in neuroblastoma [DAN], Decorin, Endoglin, Follistatin-like 1, Follistatin-like 3, Follistatin-like 4, Noggin, α2 macroglobulin, TGFβ receptor 3, Von Willebrand factor C domain-containing 2) had little or no effect. 28500669 2017
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.060 GeneticVariation disease BEFREE Bone morphogenetic proteins (BMPs) are regulated by extracellular antagonists of the DAN (differential screening-selected gene aberrative in neuroblastoma) family. 28104757 2017
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.060 Biomarker disease BEFREE Down-regulation of protein kinase C alpha and gamma and enhanced TPA-induced neurite formation in DAN-transfected neuroblastoma cells. 9862417 1998
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.060 Biomarker disease BEFREE The forced expression of DAN gene enhanced the neurite extension in the presence of RA, suggesting that DAN gene product might contain some regulatory role(s) in the RA-induced cellular differentiation in neuroblastoma cells. 9500977 1998
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.060 GeneticVariation disease BEFREE Genomic Southern experiments demonstrated that the allelic loss of DAN gene might occur in neuroblastoma. 9324305 1997
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.060 Biomarker disease BEFREE Collectively, we propose that human DAN gene is a possible candidate for a tumor suppressor gene of human neuroblastoma. 8084583 1994