TAS2R16, taste 2 receptor member 16, 50833

N. diseases: 17; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.310 Biomarker disease BEFREE These AUD-correlated probes are annotated to 36 protein-coding genes, with 16 genes (44%) having been reported by others to be related to AUD or alcohol response, including TAS2R16 and PER2. 30830696 2019
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.310 Biomarker disease CTD_human Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin. 17250611 2007
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.310 GeneticVariation disease BEFREE We have previously reported that a missense mutation in the TAS2R16 gene reduces the sensitivity of the receptor to bitter-taste stimuli and that it is associated with risk for alcohol dependence. 17250611 2007
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.310 Biomarker disease CTD_human We have previously reported that a missense mutation in the TAS2R16 gene reduces the sensitivity of the receptor to bitter-taste stimuli and that it is associated with risk for alcohol dependence. 17250611 2007
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.310 Biomarker disease CTD_human Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. 16385453 2006
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.310 Biomarker disease CTD_human Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. 16385453 2006
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		0.300 Biomarker disease CTD_human Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin. 17250611 2007
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		0.300 Biomarker disease CTD_human Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. 16385453 2006
CUI: C3148866
Disease: ALCOHOL DEPENDENCE, SUSCEPTIBILITY TO
ALCOHOL DEPENDENCE, SUSCEPTIBILITY TO 		0.100 SusceptibilityMutation phenotype CLINVAR
CUI: C4693750
Disease: BETA-GLUCOPYRANOSIDE TASTING
BETA-GLUCOPYRANOSIDE TASTING 		0.100 GeneticVariation phenotype CLINVAR
CUI: C0028043
Disease: Nicotine Dependence
Nicotine Dependence 		0.020 Biomarker disease BEFREE Finally, we applied our proposed approach to a genetic data set on tobacco dependence and found a significant interaction between two taste receptor genes (i.e., TAS2R16 and TAS2R38) in affecting nicotine dependence. 18834969 2008
CUI: C0028043
Disease: Nicotine Dependence
Nicotine Dependence 		0.020 GeneticVariation disease BEFREE To determine whether single nucleotide polymorphisms (SNPs) in TAS2R16 and TAS2R38 are associated with ND and if the effects differ by sex and ethnicity. 18524836 2008
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.010 AlteredExpression disease BEFREE This study used the human neuroblastoma SH-SY5Y cell line endogenously expressing the human bitter receptor, T2R16. 30861388 2019
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.010 AlteredExpression disease BEFREE This study used the human neuroblastoma SH-SY5Y cell line endogenously expressing the human bitter receptor, T2R16. 30861388 2019
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.010 AlteredExpression disease BEFREE This study used the human neuroblastoma SH-SY5Y cell line endogenously expressing the human bitter receptor, T2R16. 30861388 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.010 GeneticVariation disease BEFREE Our data suggest that polymorphisms within TAS2R16 gene do not have a strong influence on colon cancer susceptibility, but a possible role in rectal cancer should be further evaluated in larger cohorts. 28915899 2017
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma 		0.010 GeneticVariation disease BEFREE Our data suggest that polymorphisms within TAS2R16 gene do not have a strong influence on colon cancer susceptibility, but a possible role in rectal cancer should be further evaluated in larger cohorts. 28915899 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.010 GeneticVariation disease BEFREE Given the importance of inflammation in CRC, we tested whether polymorphic variants in this gene could affect the risk of developing this neoplasia hypothesizing a role of TAS2R16 in modulating chronic inflammation within the gut. 28915899 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 Biomarker group BEFREE Given the importance of inflammation in CRC, we tested whether polymorphic variants in this gene could affect the risk of developing this neoplasia hypothesizing a role of TAS2R16 in modulating chronic inflammation within the gut. 28915899 2017
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.010 GeneticVariation disease BEFREE Our data suggest that polymorphisms within TAS2R16 gene do not have a strong influence on colon cancer susceptibility, but a possible role in rectal cancer should be further evaluated in larger cohorts. 28915899 2017
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.010 GeneticVariation disease BEFREE Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer. 28915899 2017
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine 		0.010 GeneticVariation disease BEFREE Using a case-control study of 914 colorectal adenoma cases/1188 controls, we explored associations among colorectal adenoma risk, dietary intake, and genetic variation in 3 bitter-taste receptor genes: TAS2R38 (rs713598, rs1726866, rs10246939), TAS2R16 (rs846672), and TAS2R50 (rs1376251). 24083639 2013
CUI: C0040332
Disease: Tobacco Dependence
Tobacco Dependence 		0.010 Biomarker disease BEFREE Finally, we applied our proposed approach to a genetic data set on tobacco dependence and found a significant interaction between two taste receptor genes (i.e., TAS2R16 and TAS2R38) in affecting nicotine dependence. 18834969 2008