F11R, F11 receptor, 50848

N. diseases: 127; N. variants: 5
Disease: Arteriosclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.060 GeneticVariation disease BEFREE A peptide antagonist of F11R/JAM-A reduces plaque formation and prolongs survival in an animal model of atherosclerosis. 30877938 2019
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.060 Biomarker disease BEFREE Specific deletion of JAM-A from platelets resulted in increased reactivity and in accelerated progression of atherosclerosis. 28211187 2017
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.060 Biomarker disease BEFREE Hyperreactivity of junctional adhesion molecule A-deficient platelets accelerates atherosclerosis in hyperlipidemic mice. 25472975 2015
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.060 Biomarker disease BEFREE Our data identify endothelial JAM-A as an important effector molecule integrating atherogenic conditions to direct inflammatory cell entry at predilection sites of atherosclerosis. 24065611 2014
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.060 GeneticVariation disease BEFREE Silencing of the F11R gene reveals a role for F11R/JAM-A in the migration of inflamed vascular smooth muscle cells and in atherosclerosis. 20627246 2010
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.060 GeneticVariation disease BEFREE Based on our in-vitro and in-vivo studies to date, we propose that therapeutic drugs which antagonize the function of F11R/JAM-A should be tested as novel means for the prevention and treatment of atherosclerosis, heart attacks and stroke. 17264957 2007