|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Hypersensitivity
|
0.300 |
Biomarker
|
group |
CTD_human |
Evaluation of selected biomarkers for the detection of chemical sensitization in human skin: a comparative study applying THP-1, MUTZ-3 and primary dendritic cells in culture.
|
23624239 |
2013 |
|
Allergic Reaction
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Evaluation of selected biomarkers for the detection of chemical sensitization in human skin: a comparative study applying THP-1, MUTZ-3 and primary dendritic cells in culture.
|
23624239 |
2013 |
|
Velopharyngeal dysfunction
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
GWAS reveals loci associated with velopharyngeal dysfunction.
|
29855589 |
2018 |
|
Rheumatoid Arthritis
|
0.060 |
Biomarker
|
disease |
BEFREE |
Dendritic cell immunoreceptor (DCIR) has previously shown an association with rheumatoid arthritis (RA) in Caucasians and Han Chinese.
|
26429306 |
2015 |
|
Rheumatoid Arthritis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis confirms DCIR rs2377422 as a risk factor for ACPA-negative RA across distinct ethnic groups (OR(overall) =1.17, 95% CI 1.06-1.30, P=0.003).
|
22829930 |
2012 |
|
Rheumatoid Arthritis
|
0.060 |
Biomarker
|
disease |
BEFREE |
Given that RA and HIV-1 infections share common features such as a chronic inflammatory condition and polyclonal immune hyperactivation status, we hypothesized that HIV-1 could promote DCIR expression in CD4(+) T cells.
|
21085612 |
2010 |
|
Rheumatoid Arthritis
|
0.060 |
Biomarker
|
disease |
BEFREE |
Ligation of DCIR, or lack thereof, could contribute to the chronic inflammation characterising autoimmune diseases such as RA.
|
18250113 |
2008 |
|
Rheumatoid Arthritis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Cells with the RA-associated allele rs2024301 exhibit a significant increase in the expression of DCIR_v4.
|
18480830 |
2008 |
|
Rheumatoid Arthritis
|
0.060 |
Biomarker
|
disease |
LHGDN |
Association of arthritis with a gene complex encoding C-type lectin-like receptors.
|
17665455 |
2007 |
|
Rheumatoid Arthritis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The SNP rs1133104 in the dendritic cell immunoreceptor gene (DCIR), and a haplotype including that marker and 4 other SNPs in DCIR and its vicinity showed an indication of allelic association with susceptibility to RA in patients who were negative for antibodies to cyclic citrullinated peptide (anti-CCP), with respective odds ratios of 1.27 (95% confidence interval [95% CI] 1.06-1.52; uncorrected P = 0.0073) and 1.37 (95% CI 1.12-1.67; uncorrected P = 0.0019).
|
17665455 |
2007 |
|
Autoimmune Diseases
|
0.040 |
GeneticVariation
|
group |
BEFREE |
This study was aimed to further investigate whether DCIR polymorphisms are novel susceptibility factors for other autoimmune diseases, i.e. systemic lupus erythematosus (SLE) and primary Sjogren's syndrome (SS).
|
26429306 |
2015 |
|
Autoimmune Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
Dendritic cell immunoreceptor (DCIR) has been implicated in development of autoimmune disorders in rodent and DCIR polymorphisms were associated with anti-citrullinated proteins antibodies (ACPA)-negative rheumatoid arthritis (RA) in Swedish Caucasians.
|
22829930 |
2012 |
|
Autoimmune Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
Ligation of DCIR, or lack thereof, could contribute to the chronic inflammation characterising autoimmune diseases such as RA.
|
18250113 |
2008 |
|
Autoimmune Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
Dendritic cell immunoreceptor (DCIR) deficiency is related to development of autoimmune disorders and DCIR gene polymorphisms are associated with rheumatoid arthritis (RA).
|
18480830 |
2008 |
|
Cholesteatoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The levels of CD206 (cluster of differentiation 206), DEC-205 (Dendritic and epithelial cell-205), MGL (monoacylglycerol lipase), CLEC5A (C-type lectin domain family 5 member A), Dectin-2 (dendrite cell-associated C-type lectin-2), BDCA2 (Blood dendritic cell antigen 2), Mincle, DCIR (dendritic cell immunoreceptor), Dectin-1, MICL (Myeloid inhibitory C type-like lectin), and CLEC12B (C-type lectin domain family 12, member B) mRNAs were significantly higher in cholesteatoma than in control skin samples (p < 0.05).
|
28440726 |
2017 |
|
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The present study investigated whether downregulating the expression of Clec4a via skin delivery of small hairpin RNA (shRNA) using a gene gun produced stronger host immunity and inhibited tumor progression in animal models.
|
29246320 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, DCIR SNP rs2377422 is a novel genetic susceptibility factor for both SLE and primary SS.
|
26429306 |
2015 |
|
Primary Sjögren's syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, DCIR SNP rs2377422 is a novel genetic susceptibility factor for both SLE and primary SS.
|
26429306 |
2015 |
|
Ulcerative Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
No association was found between our IBD cohort and the candidate SNPs for DC-SIGN (CD/HC: P=0.25 and UC/HC: P=0.36), DCIR (CD/HC: P=0.22 and UC/HC: P=0.41) and MGL (CD/HC: P=0.37 and UC/HC: P=0.25).
|
22664939 |
2012 |
|
Crohn Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
No association was found between our IBD cohort and the candidate SNPs for DC-SIGN (CD/HC: P=0.25 and UC/HC: P=0.36), DCIR (CD/HC: P=0.22 and UC/HC: P=0.41) and MGL (CD/HC: P=0.37 and UC/HC: P=0.25).
|
22664939 |
2012 |
|
HIV-1 infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway.
|
21536857 |
2011 |
|
Acute infectious disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Infection studies with Vpr- or Nef-deleted viruses revealed that these two viral genes are not contributing to the mechanism of DCIR induction that is seen following acute infection of CD4(+) T cells with HIV-1.
|
21085612 |
2010 |