|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In xenograft assays, SKOV-3 cells stably overexpressing shRNA targeting PCBP1 decreased metastasis, whereas shRNA-targeting TRIM56 potentiated detection of metastatic lesions, compared to the parental SKOV-3 cells themselves.
|
30281912 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Reduction of either ILEI or LIFR protein levels results in reduced tumor growth, fewer tumor initiating cells and reduced metastasis within the hnRNP E1 knock-down cell populations in vivo.
|
30692635 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Author Correction: Expression of both poly r(C) binding protein 1 (PCBP1) and miRNA-3978 is suppressed in peritoneal gastric cancer metastasis.
|
29855506 |
2018 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In the current review, we focus on splicing factor poly(rC)-binding protein 1 (PCBP1), a novel tumor suppressor that is characterized by downregulation in many cancer types and shows inhibition of tumor formation and metastasis.
|
30132844 |
2018 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In pancreatic cancer, the present study demonstrated a novel mechanism by which Fyn/hnRNP E1 signaling regulates pancreatic cancer metastasis by affecting the alternative splicing of integrin β1. hnRNP E1 and integrin β1A are associated with the metastasis of pancreatic cancer and may be novel molecular targets for pancreatic cancer treatment.
|
28560430 |
2017 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our current study reveals PCBP1 as an additional biomarker in peritoneal metastasis.
|
29138420 |
2017 |
|
Neoplasm Metastasis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Genes that are translationally silenced by hnRNP E1 and expressed by its dissociation are highly implicated in the progression of EMT and metastasis.
|
27067543 |
2016 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In situ analysis revealed that hsa-miR-490-3p targets poly r(C)-binding protein 1 (PCBP1), which has been previously shown to be a negative regulator of lung cancer metastasis.
|
27683057 |
2016 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Cumulatively, our results indicate, pending further validation, that PCBP1 might be a prognostic marker for GBC metastasis.
|
24889597 |
2014 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Interestingly, modulation of either the steady-state expression or the posttranscriptional modification of hnRNP E1 has a temporo-spatial effect on translational repression, tumorigenesis and cancer metastasis.
|
21654215 |
2012 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Reduction of either ILEI or LIFR protein levels results in reduced tumor growth, fewer tumor initiating cells and reduced metastasis within the hnRNP E1 knock-down cell populations in vivo.
|
30692635 |
2019 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
PCBP1 can act as a suppressor of tumor in prostate epithelial cells by inhibiting MAPK1 expression.
|
30078000 |
2018 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Moreover, forced depletion of p27 counteracts the tumor suppressive ability of PCBP1 in the same PCBP1 over-expressing cells.
|
30086790 |
2018 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Taking together, PCBP1 has distinctive tumor suppressive functions, and increasing PCBP1 expression may represent a new approach for cancer treatment.
|
30132844 |
2018 |
|
Neoplasms
|
0.090 |
GeneticVariation
|
group |
BEFREE |
We identified a group of tumors in the colon and rectum lacking hypermutation and aneuploidy termed genome stable and enriched in DNA hypermethylation and mutations in KRAS, SOX9, and PCBP1.
|
29622466 |
2018 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
PCBP1 has been shown to function as a tumor suppressor by negatively regulating translation of pro-metastatic proteins in different cancers.
|
28337299 |
2017 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
While PNUTS mRNA is ubiquitously expressed, lncRNA-PNUTS appears to be tightly regulated dependent on the status of hnRNP E1 and tumour context.
|
28825698 |
2017 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Poly r(C) binding protein 1 (PCBP1) has been previously shown to function as a tumor suppressor.
|
27629145 |
2016 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Interactome analysis highlighted 14-3-3 zeta/delta, 14-3-3 beta/alpha, Alpha-actinin 4, HSP60, and PCBP1 as critical proteins in the tumor proteome signature based on their relative overconnectivity.
|
25265318 |
2014 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
TGF-beta signaling in cancer: post-transcriptional regulation of EMT via hnRNP E1.
|
29396052 |
2019 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
TGF-beta signaling in cancer: post-transcriptional regulation of EMT via hnRNP E1.
|
29396052 |
2019 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
PCBP1 could be used as a diagnostic marker to cancer patients.
|
30086790 |
2018 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
PCBP1 could be used as a diagnostic marker to cancer patients.
|
30086790 |
2018 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Previous work has shown that PCBP1 expression is inversely correlated to maintenance of cancer stem cells in squamous cell skin carcinoma and prostate cancer, respectively.
|
27629145 |
2016 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
We report here that TGF-β directly regulates alternative splicing of cancer stem cell marker CD44 through a phosphorylated T179 of SMAD3-mediated interaction with RNA-binding protein PCBP1.
|
27746021 |
2016 |