PCBP1, poly(rC) binding protein 1, 5093

N. diseases: 49; N. variants: 1
Disease: Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.090 Biomarker group BEFREE Reduction of either ILEI or LIFR protein levels results in reduced tumor growth, fewer tumor initiating cells and reduced metastasis within the hnRNP E1 knock-down cell populations in vivo. 30692635 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.090 Biomarker group BEFREE PCBP1 can act as a suppressor of tumor in prostate epithelial cells by inhibiting MAPK1 expression. 30078000 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.090 Biomarker group BEFREE Moreover, forced depletion of p27 counteracts the tumor suppressive ability of PCBP1 in the same PCBP1 over-expressing cells. 30086790 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.090 Biomarker group BEFREE Taking together, PCBP1 has distinctive tumor suppressive functions, and increasing PCBP1 expression may represent a new approach for cancer treatment. 30132844 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.090 GeneticVariation group BEFREE We identified a group of tumors in the colon and rectum lacking hypermutation and aneuploidy termed genome stable and enriched in DNA hypermethylation and mutations in KRAS, SOX9, and PCBP1. 29622466 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.090 Biomarker group BEFREE PCBP1 has been shown to function as a tumor suppressor by negatively regulating translation of pro-metastatic proteins in different cancers. 28337299 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.090 Biomarker group BEFREE While PNUTS mRNA is ubiquitously expressed, lncRNA-PNUTS appears to be tightly regulated dependent on the status of hnRNP E1 and tumour context. 28825698 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.090 Biomarker group BEFREE Poly r(C) binding protein 1 (PCBP1) has been previously shown to function as a tumor suppressor. 27629145 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.090 Biomarker group BEFREE Interactome analysis highlighted 14-3-3 zeta/delta, 14-3-3 beta/alpha, Alpha-actinin 4, HSP60, and PCBP1 as critical proteins in the tumor proteome signature based on their relative overconnectivity. 25265318 2014