PCK1, phosphoenolpyruvate carboxykinase 1, 5105

N. diseases: 73; N. variants: 12
Disease: Steatohepatitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.120 AlteredExpression disease BEFREE Overexpression of nuclear SREBP-1a under the control of the phosphoenolpyruvate carboxylase-1 (<i>Pck1</i>) promoter in mice increased hepatic <i>Hamp</i> mRNA and blood hepcidin levels, and as expected, caused fatty liver. 31270208 2019
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.120 Biomarker disease BEFREE Both hepatic PCK1 and plasma FGF21 correlated strongly and inversely with hepatic TG content, suggesting a key role for PCK1 and increased gluconeogenesis in resolving steatosis with a high-protein diet, with FGF21 expression reflecting declining cell stress. 28457799 2017
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.120 Biomarker disease HPO