Fatty Liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In vivo hepatocyte implantation studies further confirm that H19 promoted hepatic steatosis by up-regulating both mTORC1 signalling axis and MLXIPL transcriptional network.
|
31809000 |
2020 |
Fatty Liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Carbohydrate response element binding protein (ChREBP) is a key transcriptional regulator of de novo lipogenesis (DNL) in response to carbohydrates and in hepatic steatosis.
|
31227231 |
2019 |
Fatty Liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, ChREBP overexpression led to dissociation of hepatic steatosis from hyperlipidemia.
|
30405056 |
2018 |
Fatty Liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, hepatic over-expression of lipogenic transcription factor ChREBP, but not SREBP-1c, in the liver of Bmal1-LKO mice also increases fatty acid oxidation and partially reduces ethanol-induced fatty liver and liver injury.
|
29534306 |
2018 |
Fatty Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although Liver-ChREBP KO mice were protected against carbohydrate-induced hepatic steatosis, they displayed worsened glucose tolerance.
|
29107286 |
2017 |
Fatty Liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Pharmacological inhibition of liver RetSat may represent a therapeutic approach for steatosis.Fatty liver is one of the major features of metabolic syndrome and its development is associated with deregulation of systemic lipid and glucose homeostasis.Here Heidenreich et al. show that retinol saturase is implicated in hepatic lipid metabolism by regulating the activity of the transcription factor ChREBP.
|
28855500 |
2017 |
Fatty Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Findings from knockout mice and human subjects suggest that ChREBP helps to induce hepatic steatosis, dyslipidemia, and glucose intolerance.
|
27919710 |
2017 |
Fatty Liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we have shown a high complex carbohydrate diet selectively increases hepatic ChREBPβ expression, which associates with hepatic steatosis but not insulin resistance.
|
27992582 |
2016 |
Fatty Liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Diet-induced obesity increases basal expression of ChREBPβ, which may increase the risk of developing hepatic steatosis, and fructose-induced activation is independent of gluconeogenesis.
|
26526060 |
2016 |
Fatty Liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, the hypothesis is proposed that high-carbohydrate diets contribute to the association between hepatic steatosis and insulin resistance through activation of the transcription factor ChREBP (Carbohydrate response element binding protein).
|
23022226 |
2013 |
Fatty Liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Importantly, ChREBP-overexpressing mice fed a high-fat diet showed normal insulin levels and improved insulin signaling and glucose tolerance compared with controls, despite having greater hepatic steatosis.
|
22546860 |
2012 |
Fatty Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have previously reported that liver-specific inhibition of ChREBP prevents hepatic steatosis in ob/ob mice by specifically decreasing lipogenic rates in vivo.
|
21471514 |
2011 |
Fatty Liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, in mouse models of type 2 diabetes and obesity, low SIK2 activity was associated with increased p300 HAT activity, ChREBP hyperacetylation, and hepatic steatosis.
|
21084751 |
2010 |