Osteosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
To elucidate the functions of CKIP-1, we generated human osteosarcoma cell lines with tetracycline-regulated expression of Flag-CKIP-1.
|
15831458 |
2005 |
Osteosarcoma of bone
|
0.020 |
Biomarker
|
disease |
BEFREE |
To elucidate the functions of CKIP-1, we generated human osteosarcoma cell lines with tetracycline-regulated expression of Flag-CKIP-1.
|
15831458 |
2005 |
Childhood Osteosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
To elucidate the functions of CKIP-1, we generated human osteosarcoma cell lines with tetracycline-regulated expression of Flag-CKIP-1.
|
15831458 |
2005 |
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
These results indicate that CKIP-1, a novel Akt PH domain-interacting protein, would be a candidate of tumor suppressor with an Akt inhibitory function.
|
17942896 |
2007 |
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Our study indicated that high expression levels of CKIP1 were associated with the development of lung cancer, and that CKIP1 knockdown may block tumor cell growth mainly by promoting cell apoptosis.
|
25966172 |
2015 |
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CKIP1 mRNA was highly expressed both in H1299 cells and lung cancer tissues.
|
25966172 |
2015 |
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CKIP1 mRNA was highly expressed both in H1299 cells and lung cancer tissues.
|
25966172 |
2015 |
Primary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CKIP1 mRNA was highly expressed both in H1299 cells and lung cancer tissues.
|
25966172 |
2015 |
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Moreover, CKIP-1 knockdown or PI3K inhibition suppresses PAK1-mediated cell migration and invasion, demonstrating the physiological significance of the PI3K-CKIP-1-CK2-PAK1 signaling pathway.
|
26160174 |
2015 |
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Silencing of CKIP-1 promotes tumor proliferation and cell adhesion-mediated drug resistance via regulating AKT activity in non-Hodgkin's lymphoma.
|
27840970 |
2017 |
Osteosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
CKIP-1 also plays an important role in many types of cancer, such as colon, breast cancer and human osteosarcoma.
|
27840970 |
2017 |
Osteosarcoma of bone
|
0.020 |
Biomarker
|
disease |
BEFREE |
CKIP-1 also plays an important role in many types of cancer, such as colon, breast cancer and human osteosarcoma.
|
27840970 |
2017 |
Childhood Osteosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
CKIP-1 also plays an important role in many types of cancer, such as colon, breast cancer and human osteosarcoma.
|
27840970 |
2017 |
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
CKIP-1 also plays an important role in many types of cancer, such as colon, breast cancer and human osteosarcoma.
|
27840970 |
2017 |
Lymphoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In addition, adhesion of lymphoma cells to fibronectin or stroma cells (HS-5 cells) decreased CKIP-1 expression, which led to the upregulation of Akt phosphorylation.
|
27840970 |
2017 |
Lymphoma, Non-Hodgkin
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, the present study shed new light on the molecular mechanism of CAM-DR in NHL and targeting CKIP-1 may be a novel therapeutic target for NHL.
|
27840970 |
2017 |
Adult Non-Hodgkin Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Silencing of CKIP-1 promotes tumor proliferation and cell adhesion-mediated drug resistance via regulating AKT activity in non-Hodgkin's lymphoma.
|
27840970 |
2017 |
Childhood Non-Hodgkin Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Silencing of CKIP-1 promotes tumor proliferation and cell adhesion-mediated drug resistance via regulating AKT activity in non-Hodgkin's lymphoma.
|
27840970 |
2017 |
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
CKIP-1 also plays an important role in many types of cancer, such as colon, breast cancer and human osteosarcoma.
|
27840970 |
2017 |
Adult Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, adhesion of lymphoma cells to fibronectin or stroma cells (HS-5 cells) decreased CKIP-1 expression, which led to the upregulation of Akt phosphorylation.
|
27840970 |
2017 |
Childhood Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, adhesion of lymphoma cells to fibronectin or stroma cells (HS-5 cells) decreased CKIP-1 expression, which led to the upregulation of Akt phosphorylation.
|
27840970 |
2017 |
Lymphoma, Non-Hodgkin, Familial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Silencing of CKIP-1 promotes tumor proliferation and cell adhesion-mediated drug resistance via regulating AKT activity in non-Hodgkin's lymphoma.
|
27840970 |
2017 |
Osteoporosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Taken together, it suggests that the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging, indicating the translational potential of targeting PLEKHO1 in osteoblast as a novel bone anabolic strategy for reversing established osteoporosis during aging.
|
28083909 |
2017 |
Osteoporosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Targeting osteoblastic CKIP-1 would be a novel bone anabolic strategy for GIO patients.
|
28128304 |
2017 |
Septicemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, the inhibitory roles of CKIP-1 in LPS-mediated sepsis and TPA-mediated cutaneous provide a new target for treatments of acute inflammation.
|
28212865 |
2017 |