|
Osteosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
To elucidate the functions of CKIP-1, we generated human osteosarcoma cell lines with tetracycline-regulated expression of Flag-CKIP-1.
|
15831458 |
2005 |
|
Osteosarcoma of bone
|
0.020 |
Biomarker
|
disease |
BEFREE |
To elucidate the functions of CKIP-1, we generated human osteosarcoma cell lines with tetracycline-regulated expression of Flag-CKIP-1.
|
15831458 |
2005 |
|
Childhood Osteosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
To elucidate the functions of CKIP-1, we generated human osteosarcoma cell lines with tetracycline-regulated expression of Flag-CKIP-1.
|
15831458 |
2005 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
These results indicate that CKIP-1, a novel Akt PH domain-interacting protein, would be a candidate of tumor suppressor with an Akt inhibitory function.
|
17942896 |
2007 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Our study indicated that high expression levels of CKIP1 were associated with the development of lung cancer, and that CKIP1 knockdown may block tumor cell growth mainly by promoting cell apoptosis.
|
25966172 |
2015 |
|
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CKIP1 mRNA was highly expressed both in H1299 cells and lung cancer tissues.
|
25966172 |
2015 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CKIP1 mRNA was highly expressed both in H1299 cells and lung cancer tissues.
|
25966172 |
2015 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Moreover, CKIP-1 knockdown or PI3K inhibition suppresses PAK1-mediated cell migration and invasion, demonstrating the physiological significance of the PI3K-CKIP-1-CK2-PAK1 signaling pathway.
|
26160174 |
2015 |
|
Primary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CKIP1 mRNA was highly expressed both in H1299 cells and lung cancer tissues.
|
25966172 |
2015 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Silencing of CKIP-1 promotes tumor proliferation and cell adhesion-mediated drug resistance via regulating AKT activity in non-Hodgkin's lymphoma.
|
27840970 |
2017 |
|
Osteoporosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Targeting osteoblastic CKIP-1 would be a novel bone anabolic strategy for GIO patients.
|
28128304 |
2017 |
|
Osteoporosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Taken together, it suggests that the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging, indicating the translational potential of targeting PLEKHO1 in osteoblast as a novel bone anabolic strategy for reversing established osteoporosis during aging.
|
28083909 |
2017 |
|
Diabetic Nephropathy
|
0.020 |
Biomarker
|
disease |
BEFREE |
Whereas, whether PD could resist DN through regulating CKIP-1 and consequently promoting the activation of Nrf2-ARE pathway needs further investigation.
|
28286065 |
2017 |
|
Osteosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
CKIP-1 also plays an important role in many types of cancer, such as colon, breast cancer and human osteosarcoma.
|
27840970 |
2017 |
|
Renal fibrosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Experiments above suggested that PD could increase the CKIP-1-Nrf2-ARE pathway activation to prevent the OSS-induced insult in GMCs and diabetic mice which effectively postpone the diabetic renal fibrosis and the up-regulation of CKIP-1 is probably a novel mechanism in this process.
|
28286065 |
2017 |
|
Osteosarcoma of bone
|
0.020 |
Biomarker
|
disease |
BEFREE |
CKIP-1 also plays an important role in many types of cancer, such as colon, breast cancer and human osteosarcoma.
|
27840970 |
2017 |
|
Childhood Osteosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
CKIP-1 also plays an important role in many types of cancer, such as colon, breast cancer and human osteosarcoma.
|
27840970 |
2017 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
CKIP-1 also plays an important role in many types of cancer, such as colon, breast cancer and human osteosarcoma.
|
27840970 |
2017 |
|
Fatty Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results indicate that CKIP-1 deficiency in mice aggravates HFD-induced fatty liver by upregulating JNK1 phosphorylation and further upregulating IRS-1 phosphorylation and RI.
|
28351752 |
2017 |
|
Congestive heart failure
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
CKIP-1 rs2306235 polymorphism may be a risk factor for chronic heart failure in a Chinese Han population.
|
28402261 |
2017 |
|
Lymphoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In addition, adhesion of lymphoma cells to fibronectin or stroma cells (HS-5 cells) decreased CKIP-1 expression, which led to the upregulation of Akt phosphorylation.
|
27840970 |
2017 |
|
Lymphoma, Non-Hodgkin
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, the present study shed new light on the molecular mechanism of CAM-DR in NHL and targeting CKIP-1 may be a novel therapeutic target for NHL.
|
27840970 |
2017 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, RNA immunoprecipitation and chromatin immunoprecipitation assays demonstrated that DUXAP8 could epigenetically suppress the expression of PLEKHO1 by binding to EZH2 and SUZ12 (two key components of PRC2), thus promoting GC development.
|
28881724 |
2017 |
|
Septicemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, the inhibitory roles of CKIP-1 in LPS-mediated sepsis and TPA-mediated cutaneous provide a new target for treatments of acute inflammation.
|
28212865 |
2017 |
|
Adult Non-Hodgkin Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Silencing of CKIP-1 promotes tumor proliferation and cell adhesion-mediated drug resistance via regulating AKT activity in non-Hodgkin's lymphoma.
|
27840970 |
2017 |