CRBN, cereblon, 51185

N. diseases: 130; N. variants: 16
Disease: Mantle cell lymphoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4721414
Disease: Mantle cell lymphoma
Mantle cell lymphoma 		0.010 Biomarker disease BEFREE Cereblon is probably targeted by both lenalidomide and dexamethasone, which leads to synergistic cytotoxicity in MCL by inhibiting the interleukin-6/signal transducer and activator of transcription 3 (IL-6/STAT3), phosphatidylinositol 3-kinase (PI3K)/AKT and AKT2/Forkhead box O3 (FOXO3A)/BCL2-like 11 (BIM) pathways. 28529032 2017