GP6, glycoprotein VI platelet, 51206

N. diseases: 89; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1840061
Disease: SMALL PATELLA SYNDROME
SMALL PATELLA SYNDROME 		0.050 GeneticVariation disease BEFREE The objectives of the present study were to assess the genetic variability of the GP6 gene in patients with platelet hyperaggregability phenotype, known as sticky platelet syndrome (SPS) manifesting as deep vein thrombosis (DVT), and/or pulmonary embolism, and in controls; and to evaluate its role in the pathogenesis of venous thromboembolism (VTE) in SPS. 22821001 2012
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.040 GeneticVariation disease LHGDN Effect of genetic variations in platelet glycoproteins Ibalpha and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapy. 17105818 2007
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.040 GeneticVariation disease BEFREE Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients. 16493486 2006
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.040 GeneticVariation group BEFREE Large epidemiological studies should prove whether the platelet collagen receptor GPIa-IIa T807 allele is an independent risk factor for the development of stroke in younger patients. 10339462 1999
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.040 GeneticVariation disease BEFREE Our findings indicate that the A1648G polymorphism of the platelet collagen receptor plays a role in CAD in well defined patient groups. 10744142 2000
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.040 GeneticVariation disease BEFREE Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients. 16493486 2006
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.040 GeneticVariation disease BEFREE Our study showed no association between the GP VI T13254C polymorphism and CAD in either a random-effects model or a fixed-effects model. 28607925 2017
CUI: C2609046
Disease: Sticky platelet syndrome
Sticky platelet syndrome 		0.040 GeneticVariation disease BEFREE To evaluate the GP6 gene polymorphism in patients with sticky platelet syndrome (SPS) and fetal loss. 22901851 2012
CUI: C2609046
Disease: Sticky platelet syndrome
Sticky platelet syndrome 		0.040 GeneticVariation disease BEFREE The objectives of the present study were to assess the genetic variability of the GP6 gene in patients with platelet hyperaggregability phenotype, known as sticky platelet syndrome (SPS) manifesting as deep vein thrombosis (DVT), and/or pulmonary embolism, and in controls; and to evaluate its role in the pathogenesis of venous thromboembolism (VTE) in SPS. 22821001 2012
CUI: C2609046
Disease: Sticky platelet syndrome
Sticky platelet syndrome 		0.040 GeneticVariation disease BEFREE The prevalence of the platelet glycoprotein VI polymorphisms in patients with sticky platelet syndrome and ischemic stroke. 23168074 2012
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.030 GeneticVariation disease BEFREE This demonstrates that the SNPs tested within the GPVI gene are not associated with RA susceptibility and/or severity, suggesting that platelet GPVI may contribute to arthritis independently of its gene polymorphism. 23739280 2013
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.030 GeneticVariation group BEFREE Contradictory results have been published on the effects of T13254C (rs1613662), which distinguishes the two major isoforms of GP6, the gene encoding the platelet receptor glycoprotein VI, on platelet function and the risk of cardiovascular disease. 20723028 2010
CUI: C0011847
Disease: Diabetes
Diabetes 		0.030 GeneticVariation disease BEFREE Diabetes duration may modify the association between genetic variation in the glycoprotein Ia subunit of the platelet collagen receptor and risk of severe diabetic retinopathy: a working hypothesis. 12540964 2003
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.030 GeneticVariation group BEFREE Diabetes duration may modify the association between genetic variation in the glycoprotein Ia subunit of the platelet collagen receptor and risk of severe diabetic retinopathy: a working hypothesis. 12540964 2003
CUI: C0036690
Disease: Septicemia
Septicemia 		0.030 GeneticVariation disease BEFREE Additionally, patients admitted to a paediatric intensive care unit (ICU) (<i>n</i> = 73) with an initial diagnosis of sepsis were recruited and their GPVI haplotypes determined. 30597490 2019
CUI: C0243026
Disease: Sepsis
Sepsis 		0.030 GeneticVariation disease BEFREE Additionally, patients admitted to a paediatric intensive care unit (ICU) (<i>n</i> = 73) with an initial diagnosis of sepsis were recruited and their GPVI haplotypes determined. 30597490 2019
CUI: C0398650
Disease: Immune thrombocytopenic purpura
Immune thrombocytopenic purpura 		0.030 GeneticVariation disease BEFREE Patient plasma contained an autoantibody that bound specifically to GPVI-positive, normal platelets, and cleared soluble GPVI from the plasma, suggesting that the patient suffers from a rare form of idiopathic thrombocytopenic purpura caused by a GPVI-specific autoantibody that mediates clearance of the GPVI/FcRgamma-chain complex from the platelet surface. 15150079 2004
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism 		0.030 GeneticVariation phenotype BEFREE The objectives of the present study were to assess the genetic variability of the GP6 gene in patients with platelet hyperaggregability phenotype, known as sticky platelet syndrome (SPS) manifesting as deep vein thrombosis (DVT), and/or pulmonary embolism, and in controls; and to evaluate its role in the pathogenesis of venous thromboembolism (VTE) in SPS. 22821001 2012
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism 		0.030 GeneticVariation phenotype BEFREE Genetic variation of platelet glycoprotein VI and the risk of venous thromboembolism. 31699788 2019
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism 		0.030 GeneticVariation phenotype BEFREE Furthermore, reduced platelet responsiveness to PAR-1 and GPVI agonists was associated with higher risk of VTE (hazard ratio per decile increase of percentage P-selectin positive platelets: 0.73 [0.56-0.92, p=0.007] and 0.77 [0.59-0.98, p=0.034], respectively). 27761580 2017
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.020 GeneticVariation disease BEFREE Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients. 16493486 2006
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy 		0.020 GeneticVariation disease BEFREE Diabetes duration may modify the association between genetic variation in the glycoprotein Ia subunit of the platelet collagen receptor and risk of severe diabetic retinopathy: a working hypothesis. 12540964 2003
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.020 GeneticVariation disease BEFREE In this sample of white non-Hispanic men and women, several SNPs in GP6 were significantly related to risk of AMI. 20227257 2011
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.020 GeneticVariation disease BEFREE There is no association between GP VI T13254C or GP Ia C807T polymorphisms and premature acute myocardial infarction. 22627583 2012
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction 		0.010 GeneticVariation disease BEFREE The alpha2 Gene alleles of the platelet collagen receptor integrin alpha2 beta1 in Turkish children with cerebral infarct. 11323022 2001