TLR7, toll like receptor 7, 51284

N. diseases: 276; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.300 Biomarker disease MGD
CUI: C0040558
Disease: Toxoplasmosis
Toxoplasmosis 		0.010 Biomarker disease BEFREE "Triple-defective" (3d) mice carrying a mutation in UNC93B1, a chaperone for the endosomal nucleic acid-sensing (NAS) Toll-like receptors TLR3, TLR7, and TLR9, are highly susceptible to Toxoplasma gondii infection. 23290966 2013
CUI: C0021400
Disease: Influenza
Influenza 		0.090 AlteredExpression disease BEFREE 2R9 diminished systemic cytokine responses elicited in vivo by synthetic TLR2 and TLR7 agonists; it inhibited the activation of macrophages infected with influenza strain A/PR/8/34 (PR8) and significantly improved the survival of PR8-infected mice. 26095366 2015
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections 		0.020 AlteredExpression group BEFREE Herpes simplex virus 1 infection induces the expression of proinflammatory cytokines, interferons and TLR7 in human corneal epithelial cells. 16423052 2006
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia 		0.010 GeneticVariation disease BEFREE Fanconi anemia (FA) macrophages were hypersensitive to the TLR7/8 activator R848, overproducing SEAP and TNFα in response to all doses of the agonist. 22234699 2012
CUI: C3469521
Disease: FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) 		0.010 GeneticVariation disease BEFREE Fanconi anemia (FA) macrophages were hypersensitive to the TLR7/8 activator R848, overproducing SEAP and TNFα in response to all doses of the agonist. 22234699 2012
CUI: C0333983
Disease: Hyperplastic Polyp
Hyperplastic Polyp 		0.010 AlteredExpression disease BEFREE Hyperplastic polyps also showed increased TLR7 levels compared to the other polyp types. 22371291 2012
CUI: C0004096
Disease: Asthma
Asthma 		0.080 GeneticVariation disease BEFREE Asthma ever was more common (34.6%) in girls with the TLR7 variant AT or TT genotype versus those who were homozygous for the major allele A (12.5%) (p = 0.03). 28592890 2017
CUI: C0155877
Disease: Allergic asthma
Allergic asthma 		0.020 AlteredExpression disease BEFREE Allergic asthma is associated with increased levels of Th2 cytokines which are suppressed for extended periods by TLR7 agonists in a number of preclinical models of allergic airway inflammation. 29122671 2018
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.040 Biomarker disease BEFREE TLR7 agonists neutralized both of these strategies, supporting their use in SCCs and other tumors with similar immune defects. 18794336 2008
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE TLR7 agonists neutralized both of these strategies, supporting their use in SCCs and other tumors with similar immune defects. 18794336 2008
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.100 Biomarker group BEFREE Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c⁺ B-cell population is important for the development of autoimmunity. 21543762 2011
CUI: C1800706
Disease: Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis 		0.010 AlteredExpression disease BEFREE TLR7 mRNA expression levels were significantly higher in both NSCLC and IPF groups compared to controls (p=0.029, p=0.009). 22344343 2012
CUI: C0334307
Disease: Tubulovillous adenoma
Tubulovillous adenoma 		0.010 AlteredExpression disease BEFREE TLR7 expression was lower in both hyperplastic and tubulovillous adenoma polyps from patients who developed CC. 22371291 2012
CUI: C0032584
Disease: polyps
polyps 		0.010 AlteredExpression phenotype BEFREE TLR7 expression was lower in both hyperplastic and tubulovillous adenoma polyps from patients who developed CC. 22371291 2012
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.040 AlteredExpression disease BEFREE TLR7 expression was lower in both hyperplastic and tubulovillous adenoma polyps from patients who developed CC. 22371291 2012
CUI: C0858004
Disease: Influenza A virus infection
Influenza A virus infection 		0.020 Biomarker disease BEFREE TLR7 contributes to the rapid progression but not to the overall fatal outcome of secondary pneumococcal disease following influenza A virus infection. 23154432 2013
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.020 AlteredExpression group BEFREE TLR7 expression is decreased during tumour progression in transgenic adenocarcinoma of mouse prostate mice and its activation inhibits growth of prostate cancer cells. 23790156 2013
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.010 AlteredExpression disease BEFREE TLR7 agonists increased both the gene and protein expression of TLR7 and promoted production of proinflammatory cytokines/chemokines and IFN-β gene expression in prostate cancer cell lines. 23790156 2013
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.010 AlteredExpression disease BEFREE TLR7 agonists increased both the gene and protein expression of TLR7 and promoted production of proinflammatory cytokines/chemokines and IFN-β gene expression in prostate cancer cell lines. 23790156 2013
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.100 Biomarker disease BEFREE TLR7 may play an important role in the pathogenesis of psoriasis through regulating the differentiation of the keratinocytes, and will give a new insight into the psoriasis. 24057248 2013
CUI: C0031039
Disease: Pericardial effusion
Pericardial effusion 		0.010 GeneticVariation disease BEFREE TLR7 rs3853839-G (G vs. C: p = 0.0100) and TLR8 rs3764880-G (recessive model: p = 0.0173; additive model: p = 0.0161) were associated with pericardial effusion in females relative to healthy females. 24445780 2014
CUI: C0014057
Disease: Japanese Encephalitis
Japanese Encephalitis 		0.050 Biomarker disease BEFREE TLR7 is a key regulator of innate immunity against Japanese encephalitis virus infection. 24909816 2014
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.100 Biomarker group BEFREE TLR7 is a key regulator of innate immunity against Japanese encephalitis virus infection. 24909816 2014
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 AlteredExpression group BEFREE TLR 7 was expressed in all cancer specimens, but elevated expression was evident in HPV and/or p16-positive tumors. 25941114 2015