TLR7, toll like receptor 7, 51284

N. diseases: 276; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 AlteredExpression group BEFREE TLR 7 was expressed in all cancer specimens, but elevated expression was evident in HPV and/or p16-positive tumors. 25941114 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE TLR 7 was expressed in all cancer specimens, but elevated expression was evident in HPV and/or p16-positive tumors. 25941114 2015
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.070 Biomarker disease BEFREE TLR7 has previously been demonstrated to be associated with the development of pancreatic cancer, and the release of cytokines and chemokines from other types of cancer cell; however, the specific expression induced by TLR7 agonists in pancreatic cancer cells remains to be elucidated. 26718740 2016
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.070 Biomarker disease BEFREE TLR7 has previously been demonstrated to be associated with the development of pancreatic cancer, and the release of cytokines and chemokines from other types of cancer cell; however, the specific expression induced by TLR7 agonists in pancreatic cancer cells remains to be elucidated. 26718740 2016
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke 		0.010 AlteredExpression disease BEFREE TLR7 mRNA expression of the IS cases was statistically significantly higher than that of the controls in the male or female group (male, P = 0.014; female, P = 0.025). 27427388 2016
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.040 Biomarker disease BEFREE TLR7 Agonist GS-9620 Is a Potent Inhibitor of Acute HIV-1 Infection in Human Peripheral Blood Mononuclear Cells. 27799218 2017
CUI: C0151449
Disease: Primary Sjögren's syndrome
Primary Sjögren's syndrome 		0.050 Biomarker disease BEFREE TLR7 and 8 are encoded by genes localized on the X chromosome, which is especially interesting regarding the gender imbalance of pSS. 27943374 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.010 AlteredExpression group BEFREE TLR7 expressions of the good outcome group increased within 3 days following stroke onset. 28017496 2017
CUI: C1851112
Disease: Jones syndrome
Jones syndrome 		0.010 AlteredExpression disease BEFREE TLR7 mRNA levels in rCDs were also significantly elevated in comparison to the CD-GFD patients (2.11 times higher; p < 0.01). 28028951 2017
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.100 Biomarker group BEFREE TLR7/9 signals are capable of mounting massive interferon (IFN) response in plasmacytoid dendritic cells (pDCs) immediately after viral infection, yet the involvement of epigenetic regulation in this process has not been documented. 28416650 2017
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.300 Biomarker disease BEFREE Toll-like receptor 7 (TLR7) is associated with the pathophysiology of systemic lupus erythematosus and Sjögren syndrome, well-known diseases accompanying interstitial cystitis (IC). 28595240 2017
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.020 Biomarker disease BEFREE Toll-like receptor 7 (TLR7) is associated with the pathophysiology of systemic lupus erythematosus and Sjögren syndrome, well-known diseases accompanying interstitial cystitis (IC). 28595240 2017
CUI: C0282488
Disease: Interstitial Cystitis
Interstitial Cystitis 		0.010 Biomarker disease BEFREE Toll-like receptor 7 (TLR7) is associated with the pathophysiology of systemic lupus erythematosus and Sjögren syndrome, well-known diseases accompanying interstitial cystitis (IC). 28595240 2017
CUI: C0600041
Disease: Infective cystitis
Infective cystitis 		0.010 AlteredExpression disease BEFREE Toll-like receptor 7 was up-regulated in the bladder mucosa of patients with HIC, and activation of TLR7 in the mouse bladder induced cystitis with sensory hyperactivity of the bladder. 28595240 2017
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior 		0.010 AlteredExpression phenotype BEFREE Toll-like receptor 7 was up-regulated in the bladder mucosa of patients with HIC, and activation of TLR7 in the mouse bladder induced cystitis with sensory hyperactivity of the bladder. 28595240 2017
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.100 Biomarker group BEFREE TLR7 can be triggered not only by ssRNA during viral infections, but also by immune modifiers that share a similar structure to nucleosides. 28620298 2017
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.100 Biomarker group BEFREE TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy. 28652396 2017
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.010 Biomarker group BEFREE Toll-Like Receptor 7 Staining in Malignant Epithelial Tumors. 28857981 2017
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.100 Biomarker disease BEFREE TLR7 Agonist Increases Responses of Hepatitis B Virus-Specific T Cells and Natural Killer Cells in Patients With Chronic Hepatitis B Treated With Nucleos(T)Ide Analogues. 29378197 2018
CUI: C0037284
Disease: Skin lesion
Skin lesion 		0.010 Biomarker group BEFREE TLR-7 agonists are successfully used as topical treatment for various (pre)malignant skin lesions and are now under investigation as intravesical therapy for non-muscle-invasive bladder cancer. 29500135 2018
CUI: C1827293
Disease: Carcinoma of urinary bladder, invasive
Carcinoma of urinary bladder, invasive 		0.020 Biomarker disease BEFREE TLR-7 agonists are successfully used as topical treatment for various (pre)malignant skin lesions and are now under investigation as intravesical therapy for non-muscle-invasive bladder cancer. 29500135 2018
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.100 Biomarker group BEFREE Toll-like receptor 7 (TLR7) is an important molecule involved in the development of autoimmunity and the response to different pathogens. 29599669 2018
CUI: C0085409
Disease: Polyendocrinopathies, Autoimmune
Polyendocrinopathies, Autoimmune 		0.030 Biomarker group BEFREE TLR7 stimulation induced a general downregulation of miRNAs, similar to the pattern observed in SLE and APS patients. miR-361-5p, miR-128-3p and miR-181a-2-3p expression was lower in patients with a high IFN signature (false discovery rate <0.05) as compared with patients with a low IFN signature and HCs. 29873766 2018
CUI: C2062441
Disease: Influenza A
Influenza A 		0.060 Biomarker disease BEFREE Toll-like receptor 7 (TLR-7) and melanoma differentiation-associated protein 5 (MDA5) receptors showed decreased expression in influenza A infected MK1-OSU cells, while only TLR-7 expression decreased in SD-PJEC cells. 29880757 2018
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.300 Biomarker disease BEFREE TLR7 activation is an important contributor to systemic lupus erythematosus pathogenesis, but the mechanisms by which type I IFNs participate in TLR7-driven pathologic conditions remain uncertain. 29884703 2018