KRT76, keratin 76, 51350

N. diseases: 8; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.300 GeneticVariation disease UNIPROT
CUI: C0497156
Disease: Lymphadenopathy
Lymphadenopathy 		0.010 Biomarker phenotype BEFREE We show that genetic ablation of Krt76 in mice leads to spleen and lymph node enlargement, an increase in regulatory T cells (Tregs) and high levels of pro-inflammatory cytokines. 30143634 2018
CUI: C0037274
Disease: Dermatologic disorders
Dermatologic disorders 		0.010 Biomarker group BEFREE These observations establish a previously unknown connection between the intermediate filament cytoskeleton network and tight junctions and showcase Krt76 null mice as a possible model to study aberrant tight junction driven skin diseases. 25340345 2014
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.010 AlteredExpression group BEFREE Here we evaluate the role of KRT76 downregulation in oral precancer and cancer development. 23936238 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 Biomarker group BEFREE Thus, future studies to investigate the contributing role of KRT76 in light of other tumor driving events are warranted. 23936238 2013
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth 		0.010 Biomarker group BEFREE The KRT76-KO mice data underlines the potential of KRT76 being an early event although this loss is not sufficient to drive the development of oral cancers. 23936238 2013
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.010 AlteredExpression phenotype BEFREE Downregulation of keratin 76 expression during oral carcinogenesis of human, hamster and mouse. 23936238 2013
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.010 AlteredExpression group BEFREE Here we evaluate the role of KRT76 downregulation in oral precancer and cancer development. 23936238 2013