PDE3A, phosphodiesterase 3A, 5139

N. diseases: 58; N. variants: 23
Disease: Gastrointestinal Stromal Tumors ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0238198
Disease: Gastrointestinal Stromal Tumors
Gastrointestinal Stromal Tumors 		0.040 Biomarker group BEFREE Our results highlight the potential use of compounds targeting PDE3A or YAP in combined multitherapy to tackle GIST resistance. 30956759 2019
CUI: C0238198
Disease: Gastrointestinal Stromal Tumors
Gastrointestinal Stromal Tumors 		0.040 AlteredExpression group BEFREE GISTs expressed PDE3A and PDE3B frequently compared with other human normal or cancerous tissues both in the <i>in silico</i> database and the TMAs. 30530703 2019
CUI: C0238198
Disease: Gastrointestinal Stromal Tumors
Gastrointestinal Stromal Tumors 		0.040 AlteredExpression group BEFREE Finally, we demonstrate that PDE3A is highly expressed in subsets of patient tumor cell samples from different solid cancer diagnoses and expressed at exceptional levels in gastrointestinal stromal tumor (GIST) specimens. 29107068 2017
CUI: C0238198
Disease: Gastrointestinal Stromal Tumors
Gastrointestinal Stromal Tumors 		0.040 Biomarker group BEFREE Our results suggest a role for PDE3A during ICC development and open novel perspectives for PDE3A in targeted GIST therapy, on one hand by the synergism between imatinib and cilostazol, a PDE3 inhibitor already in clinical use for other indications, and, on the other hand, by the neomorphic, druggable, PDE3A-SLFN12 cytotoxic interplay. 28454120 2017