PDE4A, phosphodiesterase 4A, 5141

N. diseases: 168; N. variants: 3
Disease: Respiration Disorders ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0035204
Disease: Respiration Disorders
Respiration Disorders 		0.030 AlteredExpression group BEFREE Cyclic nucleotide phosphodiesterase type 4 (PDE4), that controls intracellular level of cyclic nucleotide cAMP, has aroused scientific attention as a suitable target for anti-inflammatory therapy in respiratory diseases. 29407945 2018
CUI: C0035204
Disease: Respiration Disorders
Respiration Disorders 		0.030 Biomarker group BEFREE Discovery and Optimization of Thiazolidinyl and Pyrrolidinyl Derivatives as Inhaled PDE4 Inhibitors for Respiratory Diseases. 29200281 2017
CUI: C0035204
Disease: Respiration Disorders
Respiration Disorders 		0.030 Biomarker group BEFREE This review highlights the major advantages of the selective specific inhibition of PDE4A, B, C, and D versus selective, non-specific inhibitors as treatments for chronic respiratory diseases. 28201975 2017