PDE4A, phosphodiesterase 4A, 5141

N. diseases: 168; N. variants: 3
Disease: Severe chronic obstructive pulmonary disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0730607
Disease: Severe chronic obstructive pulmonary disease
Severe chronic obstructive pulmonary disease 		0.030 Biomarker disease BEFREE Currently, the selective PDE4 inhibitor roflumilast is an approved add-on treatment for patients with severe chronic obstructive pulmonary disease with chronic bronchitis and a history of frequent exacerbations. 31664853 2020
CUI: C0730607
Disease: Severe chronic obstructive pulmonary disease
Severe chronic obstructive pulmonary disease 		0.030 Biomarker disease BEFREE Roflumilast is a selective phosphodiesterase type 4 (PDE4) inhibitor used clinically for severe chronic obstructive pulmonary disease, but the effects to the brain have not been well investigated. 29441434 2018
CUI: C0730607
Disease: Severe chronic obstructive pulmonary disease
Severe chronic obstructive pulmonary disease 		0.030 Biomarker disease BEFREE Roflumilast is a selective PDE4 inhibitor, used for the treatment of severe chronic obstructive pulmonary disease in clinic. 28650427 2017