Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.410 GeneticVariation disease GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.410 AlteredExpression disease BEFREE In addition, we found significantly higher CHMP5 mRNA levels in acute myeloid leukemia patients. 20734392 2011
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.410 Biomarker disease CTD_human [Correlation between expression of apoptosis-related gene pnas-2 and leukemia]. 17708794 2007
CUI: C0026998
Disease: Acute Myeloid Leukemia, M1
Acute Myeloid Leukemia, M1 		0.300 Biomarker disease CTD_human [Correlation between expression of apoptosis-related gene pnas-2 and leukemia]. 17708794 2007
CUI: C1879321
Disease: Acute Myeloid Leukemia (AML-M2)
Acute Myeloid Leukemia (AML-M2) 		0.300 Biomarker disease CTD_human [Correlation between expression of apoptosis-related gene pnas-2 and leukemia]. 17708794 2007
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.040 Biomarker disease BEFREE The Homo sapiens charged multivesicular body protein 5 (CHMP5) is a member of the multivesicular body, which serves as an anti-apoptotic protein and is thought to participate in leukemogenesis. 23619569 2013
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.040 AlteredExpression disease BEFREE Over-expressed CHMP5 was found to act as oncogene that probably participated in leukemogenesis. 22609838 2012
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.040 Biomarker disease BEFREE This observation together with the antiapoptotic feature of CHMP5 suggests a possible oncogenic function for this gene in leukemogenesis. 20734392 2011
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.040 Biomarker disease BEFREE In this study, we tried to clarify the role of PNAS-2 in apoptosis and leukemogenesis. 17855796 2006
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.010 Biomarker disease BEFREE We found that MIR429 inhibited colon cancer cell growth and cell cycle progression, and CHMP5 was overexpressed in the DSS-induced colitis mouse model and human ulcerative colitis (UC) tissues. 30334065 2018
CUI: C0009319
Disease: Colitis
Colitis 		0.010 AlteredExpression disease BEFREE We found that MIR429 inhibited colon cancer cell growth and cell cycle progression, and CHMP5 was overexpressed in the DSS-induced colitis mouse model and human ulcerative colitis (UC) tissues. 30334065 2018
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.010 AlteredExpression disease BEFREE Our findings show that CHMP5 is a direct target of MIR429 in human colon cancer cell lines and suggest that CHMP5 up-regulation as a result of reduced MIR429 expression in DSS-induced mice colitis tissues and human UC tissues may restrict apoptosis and promote cell proliferation. 30334065 2018
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.010 Biomarker disease BEFREE We found that MIR429 inhibited colon cancer cell growth and cell cycle progression, and CHMP5 was overexpressed in the DSS-induced colitis mouse model and human ulcerative colitis (UC) tissues. 30334065 2018
CUI: C0039685
Disease: Tetralogy of Fallot
Tetralogy of Fallot 		0.010 Biomarker disease BEFREE RV ejection fraction (EF) was normal and similar between TOF and VPS (60 and 65%, respectively, p = 0.8). 28144689 2017
CUI: C0035369
Disease: Retroviridae Infections
Retroviridae Infections 		0.010 Biomarker group BEFREE Anti-CHMP5 single chain variable fragment antibody retrovirus infection induces programmed cell death of AML leukemic cells in vitro. 22609838 2012
CUI: C0023418
Disease: leukemia
leukemia 		0.010 AlteredExpression disease BEFREE In carcinomas, PNAS-2 expression was not upregulated, indicating that PNAS-2 overexpression was specific for leukemia. 17855796 2006
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.010 AlteredExpression disease BEFREE PNAS-2 expression is significantly increased in de novo or relapsed acute leukemia, but in patients in complete remission PNAS-2 levels decrease to levels comparable to those found in normal controls. 17855796 2006
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.010 AlteredExpression disease BEFREE In carcinomas, PNAS-2 expression was not upregulated, indicating that PNAS-2 overexpression was specific for leukemia. 17855796 2006