SIRT6, sirtuin 6, 51548

N. diseases: 195; N. variants: 2
Disease: Steatohepatitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.060 Biomarker disease BEFREE Here, we demonstrate that XBP1s is a deacetylation target of Sirt6 and that its deacetylation protects against ER stress-induced hepatic steatosis. 31541078 2019
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.060 Biomarker disease BEFREE SIRT6 is abundant in the liver and is a crucial target for patients with liver steatosis. 30078674 2018
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.060 AlteredExpression disease BEFREE Sirt6 overexpression markedly ameliorated the effects of USP10 deficiency in hepatic steatosis, insulin resistance, and inflammation. 29698567 2018
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.060 Biomarker disease BEFREE Sirt6 deficiency leads to liver steatosis and promotes diet-induced obesity and insulin resistance. 29535637 2018
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.060 Biomarker disease BEFREE Sirtuin (Sirt)6 has been implicated in negative regulation of inflammation and lipid metabolism, although its function in the progression from simple steatosis to nonalcoholic steatohepatitis (NASH) remains to be defined. 28536120 2017
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.060 AlteredExpression disease BEFREE Human fatty liver samples exhibited significantly lower levels of SIRT6 than did normal controls. 20816089 2010