|
Chronic Lymphocytic Leukemia
|
0.070 |
Biomarker
|
disease |
BEFREE |
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia.
|
12434020 |
2002 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Therefore, miR15 and miR16 down-regulation in pituitary adenomas correlates with a greater tumor diameter and a lower p43 secretion, suggesting that these genes may, at least in part, influence tumor growth.
|
15648093 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, miR-15 and miR-16 are natural antisense Bcl2 interactors that could be used for therapy of Bcl2-overexpressing tumors.
|
16166262 |
2005 |
|
Chronic Lymphocytic Leukemia
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Some human miRNAs are linked to leukemias: the miR-15a/miR-16 locus is frequently deleted or down-regulated in patients with B-cell chronic lymphocytic leukemia and miR-142 is at a translocation site found in a case of aggressive B-cell leukemia.
|
15737576 |
2005 |
|
B-CELL MALIGNANCY, LOW-GRADE
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Some human miRNAs are linked to leukemias: the miR-15a/miR-16 locus is frequently deleted or down-regulated in patients with B-cell chronic lymphocytic leukemia and miR-142 is at a translocation site found in a case of aggressive B-cell leukemia.
|
15737576 |
2005 |
|
Leukemia, B-Cell
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Some human miRNAs are linked to leukemias: the miR-15a/miR-16 locus is frequently deleted or down-regulated in patients with B-cell chronic lymphocytic leukemia and miR-142 is at a translocation site found in a case of aggressive B-cell leukemia.
|
15737576 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, miR-15 and miR-16 are natural antisense Bcl2 interactors that could be used for therapy of Bcl2-overexpressing tumors.
|
16616063 |
2006 |
|
Neuroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
For example, miR-15 and miR-16 induce apoptosis by targeting Bcl2. miRNAs from the miR-17-92 cluster modulate tumor formation and function as oncogenes by influencing the translation of E2F1 mRNA. miR-21 modulates gemcitabine-induced apoptosis by phosphatase and tensin homolog deleted on chromosome 10-dependent activation of PI 3-kinase signaling. miR-34a acts as a suppressor of neuroblastoma tumorigenesis by targeting the mRNA encoding E2F3 and reducing E2F3 protein levels.
|
17894887 |
2007 |
|
Central neuroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
For example, miR-15 and miR-16 induce apoptosis by targeting Bcl2. miRNAs from the miR-17-92 cluster modulate tumor formation and function as oncogenes by influencing the translation of E2F1 mRNA. miR-21 modulates gemcitabine-induced apoptosis by phosphatase and tensin homolog deleted on chromosome 10-dependent activation of PI 3-kinase signaling. miR-34a acts as a suppressor of neuroblastoma tumorigenesis by targeting the mRNA encoding E2F3 and reducing E2F3 protein levels.
|
17894887 |
2007 |
|
Childhood Neuroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
For example, miR-15 and miR-16 induce apoptosis by targeting Bcl2. miRNAs from the miR-17-92 cluster modulate tumor formation and function as oncogenes by influencing the translation of E2F1 mRNA. miR-21 modulates gemcitabine-induced apoptosis by phosphatase and tensin homolog deleted on chromosome 10-dependent activation of PI 3-kinase signaling. miR-34a acts as a suppressor of neuroblastoma tumorigenesis by targeting the mRNA encoding E2F3 and reducing E2F3 protein levels.
|
17894887 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Altogether, we propose that miR-15a and miR-16 act as tumor suppressor genes in prostate cancer through the control of cell survival, proliferation and invasion.
|
18931683 |
2008 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Altogether, we propose that miR-15a and miR-16 act as tumor suppressor genes in prostate cancer through the control of cell survival, proliferation and invasion.
|
18931683 |
2008 |
|
Malignant neoplasm of prostate
|
0.090 |
Biomarker
|
disease |
BEFREE |
Altogether, we propose that miR-15a and miR-16 act as tumor suppressor genes in prostate cancer through the control of cell survival, proliferation and invasion.
|
18931683 |
2008 |
|
Prostate carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Altogether, we propose that miR-15a and miR-16 act as tumor suppressor genes in prostate cancer through the control of cell survival, proliferation and invasion.
|
18931683 |
2008 |
|
Immunologic Deficiency Syndromes
|
0.020 |
Biomarker
|
group |
BEFREE |
Delivery of antagomirs specific for miR-15a and miR-16 to normal mouse prostate results in marked hyperplasia, and knockdown of miR-15a and miR-16 promotes survival, proliferation and invasiveness of untransformed prostate cells, which become tumorigenic in immunodeficient NOD-SCID mice.
|
18931683 |
2008 |
|
Carcinoma, Papillary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, when analyzed according to specific cancer phenotypes, miR-15a and miR-16 show a significant downregulation in canine ductal carcinomas while miRsR-181b, -21, -29b, and let-7f show a significant upregulation in canine tubular papillary carcinomas.
|
18665421 |
2008 |
|
Ductal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, when analyzed according to specific cancer phenotypes, miR-15a and miR-16 show a significant downregulation in canine ductal carcinomas while miRsR-181b, -21, -29b, and let-7f show a significant upregulation in canine tubular papillary carcinomas.
|
18665421 |
2008 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These findings suggest the development of therapeutic strategies by restoring miR-15a and miR-16 expression in ovarian cancer and in other cancers that involve upregulation of Bmi-1.
|
19903841 |
2009 |
|
Non-Small Cell Lung Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In non-small cell lung cancer (NSCLC) cell lines, cyclins D1, D2, and E1 are directly regulated by physiologic concentrations of miR-15a/miR-16.
|
19549910 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We found that the tumor suppressor BRCA-1 is a target of miR-15a as well as miR-16, suggesting a miRNA role in NPC pathogenesis.
|
19144710 |
2009 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our results indicate that miR-15a/miR-16 are implicated in cell cycle control and likely contribute to the tumorigenesis of NSCLC.
|
19549910 |
2009 |
|
Nasopharyngeal carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
We found that the tumor suppressor BRCA-1 is a target of miR-15a as well as miR-16, suggesting a miRNA role in NPC pathogenesis.
|
19144710 |
2009 |
|
Squamous cell carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that miR-15a/miR-16 are frequently deleted or down-regulated in squamous cell carcinomas and adenocarcinomas of the lung.
|
19549910 |
2009 |
|
Adenocarcinoma
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Here, we show that miR-15a/miR-16 are frequently deleted or down-regulated in squamous cell carcinomas and adenocarcinomas of the lung.
|
19549910 |
2009 |
|
leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
Since the discovery of miR-15 and miR-16 in CLL, much effect has been done to investigate the small molecule in leukemia.
|
19106636 |
2009 |