|
Major Depressive Disorder
|
0.330 |
Biomarker
|
disease |
BEFREE |
Serum-based microRNA biomarkers for major depression: MiR-16, miR-135a, and miR-1202.
|
30181751 |
2018 |
|
Major Depressive Disorder
|
0.330 |
Biomarker
|
disease |
BEFREE |
Investigation of miR-1202, miR-135a, and miR-16 in Major Depressive Disorder and Antidepressant Response.
|
28520926 |
2017 |
|
Major Depressive Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
CSF miR-16 in MDD patients was significantly lower than that in controls.
|
25779937 |
2015 |
|
Major Depressive Disorder
|
0.330 |
Biomarker
|
disease |
BEFREE |
CSF miR-16 in MDD patients was significantly lower than that in controls.
|
25779937 |
2015 |
|
Unipolar Depression
|
0.320 |
Biomarker
|
disease |
BEFREE |
Serum-based microRNA biomarkers for major depression: MiR-16, miR-135a, and miR-1202.
|
30181751 |
2018 |
|
Unipolar Depression
|
0.320 |
Biomarker
|
disease |
BEFREE |
Investigation of miR-1202, miR-135a, and miR-16 in Major Depressive Disorder and Antidepressant Response.
|
28520926 |
2017 |
|
Unipolar Depression
|
0.320 |
Biomarker
|
disease |
PSYGENET |
CSF miR-16 is decreased in major depression patients and its neutralization in rats induces depression-like behaviors via a serotonin transmitter system.
|
25779937 |
2015 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
MDA-MB-231 and SK-BR-3 human breast cancer cell lines were cultured and transfected twice with hsa-miR-16-5p and hsa-miR-34a-5p mimics individually or in combination.
|
30916815 |
2019 |
|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
ADM-sensitive (MCF-7/S) and -resistant (MCF-7/A) BC cell lines were used to determine the expression of miR-16 prior to and following transfection with miR-16 mimics or inhibitor.
|
31452770 |
2019 |
|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This research aims at investigating the miR-16-5p expression and its effect on the pathogenesis of breast cancer.
|
31383783 |
2019 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Total RNA was extracted using the miRNeasy Mini Kit and the expression of miRs frequently dysregulated in pancreatobiliary cancer (miR-16, miR-21, miR-196a, miR-221) were analyzed by quantitative real-time PCR using RNU6B as internal control.
|
31400934 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We provided a comprehensive view of the diagnostic value of serum miR-16 in cancer diagnosis, and confirmed that circulating miR-16 could play an important role in cancer detection.
|
30706130 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transferrin-decorated thymoquinone-loaded PEG-PLGA nanoparticles exhibit anticarcinogenic effect in non-small cell lung carcinoma via the modulation of miR-34a and miR-16.
|
31411213 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TDownstream RGS4 targets (eg, miR-16 and BDNF) might be involved in the development of NSCLC and may serve as potential therapeutic targets for its treatment.
|
31695428 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression level of miR-16 was negatively correlated to the clinical staging of NSCLC.
|
31298377 |
2019 |
|
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Effects of miR-16-5p treated with CRC cells in regard to CRC in vivo were also measured.
|
31102273 |
2019 |
|
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the present study demonstrated that SNHG12 promotes CRC cell proliferation and invasion, at least in part, by acting as a molecular sponge of miR-16, suggesting that SNHG12 may be a promising therapeutic target for CRC.
|
31316616 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Effects of miR-16-5p on glioma cell viability, apoptosis and response to irradiation and temozolomide (TMZ) were assessed.
|
30548945 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The regulatory cascade LINC00515/miR-16/PRMT5 plays a critical role in glioma progression.
|
31114220 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Long non-coding RNA AGAP2-AS1, functioning as a competitive endogenous RNA, upregulates ANXA11 expression by sponging miR-16-5p and promotes proliferation and metastasis in hepatocellular carcinoma.
|
31088485 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, down-regulation of IGF1R significantly reduced the inhibitory effect of miR-16-5p on the proliferation and metastasis of SMMC-7721 cells.
|
30657555 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Knocking down of sONE resulted in a marked decrease in TP53 and increase in c-Myc and consequently altering the expression status of their downstream tumor suppressor microRNAs (miRNAs) such as miR-34a, miR-15, miR-16, and let-7a.
|
30968427 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Although the tumor suppressor function of intracellular miR-16 in MM plasma cells (PCs) has been elucidated, its extracellular role in maintaining a nonsupportive cancer microenvironment has not been fully explored.
|
31593552 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The present study demonstrates that miR-16 acts as a tumor-suppressor gene by inhibiting the proliferation, migration, and invasion of NSCLC cells via downregulating MMP-19 expression.
|
31298377 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We aimed to characterize the role of miR-16-5p as a candidate tumour suppressor miRNA in gliomas.
|
30548945 |
2019 |