PDK4, pyruvate dehydrogenase kinase 4, 5166

N. diseases: 85; N. variants: 5
Disease: Diabetes Mellitus ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.060 Biomarker group BEFREE This peculiar methylation on CpG site 6 of PDK4 promoter in the blood sample before the hyperglycemic period might serve as a potential biomarker for early detection of diabetes in the patients. 31655976 2020
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.060 AlteredExpression group BEFREE Cumulative evidence has shown that the up-regulation of PDK4 expression is tightly associated with obesity and diabetes. 29656110 2018
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.060 Biomarker group BEFREE This finding strengthens the possibility of PDK4 as a target against diabetes. 30065033 2018
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.060 Biomarker group BEFREE Elevated PDK4 and UCP3 and reduced pyruvate usage were present 24 h after diabetes induction. 29610263 2018
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.060 AlteredExpression group BEFREE Since hyperactivation of PDK4 has been reported in calcified vessels and in patients with diabetes mellitus, inhibition of PDK4 expression may be a strategy for the prevention of diabetic vascular calcification. 29348870 2017
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.060 Biomarker group BEFREE Pyruvate dehydrogenase kinase 4 (PDK4), a mammalian mitochondrial serine kinase has emerged as an interesting candidate for diabetes therapy. 25794976 2015