Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our study pointed out the role of MC4R rs17782313 and ENPP1 rs1044498 genotypes in obesity determinisms in mothers and their newborns in correlation with BMI, MUAC, TST and bioimpedance parameters.
|
31350533 |
2019 |
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We found that: (1) Obese GDM patients have higher AT ENPP1 expression than obese non-GDM patients, or controls (P = 0.01-ANOVA).
|
28080219 |
2017 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
However, we found no association of ENPP1 rs1044498 with obesity (BMI ≧ 27 kg/m(2)).
|
27238374 |
2016 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we found nominal associations between obesity risk or BMI variation and the following SNPs: ENPP1 rs7754561, MC4R rs17782313 and NEGR1 rs2815752.
|
23375129 |
2013 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Amerindians show no association of PC-1 gene Gln121 allele and obesity: a thrifty gene population genetics.
|
22327785 |
2012 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The ENPP1 Q121 variant predicts major cardiovascular events in high-risk individuals: evidence for interaction with obesity in diabetic patients.
|
21282363 |
2011 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The results from the present study have indicated that ENPP1/PC1 Q121 variant may increase the risk of obesity and that more well-designed studies based on a larger population will be required to further evaluate the role of ENPP1/PC1 gene K121Q polymorphism in obesity and other related metabolic syndromes.
|
21565692 |
2011 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our study did not replicate the positive association found previously and suggested that K121Q of ENPP1 might not have a major role in the susceptibility to T2D or obesity in the Chinese Han population.
|
20981035 |
2011 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The K121Q polymorphism of the ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been studied in relation to insulin resistance, type 2 diabetes, and obesity, and conflicting results were observed in various populations.
|
21452007 |
2011 |
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
The gene encoding ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is a candidate susceptibility gene for obesity and type 2 diabetes.
|
21198320 |
2011 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Possible role for ENPP1 polymorphism in obesity but not for INSIG2 and PLIN variants.
|
19399648 |
2009 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Although there was no evidence of an association between the ENPP1 K121Q variant and the general phenotype of T2D, we did find an association with adult obesity and T2D.
|
19046915 |
2009 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Because insulin resistance is a pivotal factor in the development of metabolic syndrome (MS) and impaired glucose tolerance (IGT), we aimed to test the association between the K121Q and rs997509 ENPP-1 variants with obesity, MS and IGT in obese children and adolescents.
|
18940878 |
2009 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This is the first child-based study showing a protective role of the 121Q variant of ENPP1 against overweight/obesity.
|
18948963 |
2009 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In addition, the previously reported ENPP1/PC-1 "risk haplotype" (Q (rs1044498), delT (rs1799774), and G (rs7754561) alleles) was found to be associated with obesity in male, but not in female, subjects (P = 0.035).
|
18719658 |
2008 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We genotyped 106 single-nucleotide polymorphisms (SNPs) within ENPP1 in all 439 subjects from the linkage study, and measured association with obesity and metabolic syndrome (MS)-related traits.
|
18464750 |
2008 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The single nucleotide polymorphism (SNP) K121Q in the ENPP1 gene has been studied in relation to obesity, insulin resistance and other features of MS in several populations with conflicting results.
|
17986276 |
2008 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We concluded that the ENPP1 121Q allele is not a critical determinant for either diabetes or obesity in Korean males.
|
18583883 |
2008 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Weaker associations were detected between the SNPs rs1541276 in the MC5R, rs1926065 in the MC3R genes and obesity (P = 0.04 and P = 0.03, respectively), and between SNPs rs2236700 in the MC5R, rs2118404 in the POMC, rs943003 in the ENPP1 genes and type 2 diabetes (P = 0.03, P = 0.02 and P = 0.02, respectively); these associations did not, however, remain significant after correction for multiple testing.
|
18551113 |
2008 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The K121Q variant of the ectonucleotide pyrophosphatase/ phosphodiesterase 1 (ENPP1) gene is associated with obesity, insulin resistance, and early myocardial infarction.
|
18389334 |
2008 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study.
|
17704904 |
2007 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The K121Q polymorphism in ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is associated with type 2 diabetes and obesity.
|
16936213 |
2006 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we find no evidence that previously associated variants of ENPP1 are associated with type 2 diabetes or obesity in the U.K. population.
|
17065358 |
2006 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to determine whether K121Q polymorphism in PC-1 gene is involved in obesity susceptibility in Chinese Han population.
|
17026496 |
2006 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity.
|
17065359 |
2006 |