|
Age at menopause
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
mathematical ability
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
|
30038396 |
2018 |
|
Age at menarche
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Elucidating the genetic architecture of reproductive ageing in the Japanese population.
|
29773799 |
2018 |
|
Age at menopause
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
|
26414677 |
2015 |
|
Age at menopause
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
|
22267201 |
2012 |
|
Age at menopause
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
|
22267201 |
2012 |
|
Age at menopause
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.
|
19448621 |
2009 |
|
Age at menopause
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.
|
19448621 |
2009 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Here we show that in the BRCA1-A complex structure, ABRAXAS integrates the DNA repair protein RAP80 and provides a high-affinity binding site that sequesters the tumor suppressor BRCA1 away from the break site.
|
31253574 |
2019 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
RAP80 expression was related to tumor size, lymph node metastasis, TNM stage, and molecular subtype (<i>P</i><0.05).
|
30705591 |
2019 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
RAP80 has been reported to affect outcome in some solid neoplasms.
|
27443420 |
2017 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
BRCA1 PARsylation and/or RAP80 expression is defective in a subset of sporadic breast cancer cell lines and patient-derived tumor xenograft models.
|
25252691 |
2014 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Identification of TOV-21G as a RAP80 null tumor cell line will be very useful for the study of the molecular mechanism in DNA damage response.
|
22792303 |
2012 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Quantitative PCR or immunohistochemistry were used to analyze the expression of β-tubuline IIA (TUBB2A), β-tubuline III (TUBB3), BRCA1, ERCC1, Abraxas (ABRX) and RAP80 in mRNA isolated from paraffin-embedded tumor biopsies of 45 NSCLC patients treated as part of a larger observational trial.
|
21529986 |
2011 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
There are several RAP80/UIMC1 isoforms that are predominantly expressed in testis, however we did not observe elevated expression of these transcripts in tumors from seropositive patients.
|
17562356 |
2007 |
|
Malignant neoplasm of breast
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
RAP80 expression in breast cancer (62.3%, 101/162) was significantly lower than that in adjacent normal breast tissues (<i>P</i><0.05).
|
30705591 |
2019 |
|
Breast Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
RAP80 expression in breast cancer (62.3%, 101/162) was significantly lower than that in adjacent normal breast tissues (<i>P</i><0.05).
|
30705591 |
2019 |
|
Malignant neoplasm of breast
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Association between the epithelial growth factor receptor (EGFR) mutation and the expression of breast cancer 1 (BRCA1) and receptor-associated protein 80 (RAP80) in non-small cell lung cancer (NSCLC) was studied.
|
30008919 |
2018 |
|
Breast Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Association between the epithelial growth factor receptor (EGFR) mutation and the expression of breast cancer 1 (BRCA1) and receptor-associated protein 80 (RAP80) in non-small cell lung cancer (NSCLC) was studied.
|
30008919 |
2018 |
|
Malignant neoplasm of breast
|
0.060 |
Biomarker
|
disease |
BEFREE |
Mutation screening of the MERIT40 gene encoding a novel BRCA1 and RAP80 interacting protein in breast cancer families.
|
19572197 |
2010 |
|
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Mutation screening of the MERIT40 gene encoding a novel BRCA1 and RAP80 interacting protein in breast cancer families.
|
19572197 |
2010 |
|
Malignant neoplasm of breast
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
A novel RAP80 haplotype or rare missense mutations may be associated with a modest increased risk of breast cancer, but this observation needs to be confirmed by additional studies.
|
18306035 |
2009 |
|
Malignant neoplasm of breast
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Conclusions Overall, it seems unlikely that moderate to highly penetrant alleles of either RAP80 or Abraxas, confer a significantly high relative risk of breast cancer.
|
18695986 |
2009 |
|
Malignant neoplasm of breast
|
0.060 |
Biomarker
|
disease |
BEFREE |
Our analysis suggests that RAP80 and CCDC98 do not play an important role as high penetrance breast cancer susceptibility genes.
|
18270812 |
2009 |
|
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Our analysis suggests that RAP80 and CCDC98 do not play an important role as high penetrance breast cancer susceptibility genes.
|
18270812 |
2009 |