GHRL, ghrelin and obestatin prepropeptide, 51738

N. diseases: 183; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.500 SusceptibilityMutation disease CLINVAR
CUI: C0028754
Disease: Obesity
Obesity 		0.500 Biomarker disease CTD_human
CUI: C0028754
Disease: Obesity
Obesity 		0.500 Biomarker disease HPO
CUI: C2676079
Disease: METABOLIC SYNDROME, SUSCEPTIBILITY TO
METABOLIC SYNDROME, SUSCEPTIBILITY TO 		0.100 SusceptibilityMutation phenotype CLINVAR
CUI: C4016925
Disease: OBESITY, AGE AT ONSET OF
OBESITY, AGE AT ONSET OF 		0.100 CausalMutation phenotype CLINVAR
CUI: C4022947
Disease: Decreased resting energy expenditure
Decreased resting energy expenditure 		0.100 Biomarker phenotype HPO
CUI: C4703554
Disease: Increased waist to hip ratio
Increased waist to hip ratio 		0.100 Biomarker phenotype HPO
CUI: C0001430
Disease: Adenoma
Adenoma 		0.020 AlteredExpression group BEFREE We examined the expression of functional growth hormone secretagogue receptors (GHS-R) in a series of 30 human pituitary adenomas-six secreting GH, three GH-PRL, six prolactin (PRL), five adrenocorticotrophic hormone (ACTH), one thyroid stimulating hormone (TSH), four gonadotroph and five non-secreting adenomas. 10444306 1999
CUI: C0028754
Disease: Obesity
Obesity 		0.500 GeneticVariation disease BEFREE Mutations in the preproghrelin/ghrelin gene associated with obesity in humans. 11502844 2001
CUI: C0028756
Disease: Obesity, Morbid
Obesity, Morbid 		0.010 Biomarker disease BEFREE Ghrelin and preproghrelin sequences were determined in 96 unrelated female subjects with severe obesity (mean body mass index (BMI) 42.3 +/- 3.4 kg/m(2)) and in 96 non-obese female controls (mean BMI 23.0 +/- 1.4 (kg/m2) of the Swedish Obese Subjects cohort. 11502844 2001
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome 		0.070 AlteredExpression disease LHGDN Circulating ghrelin levels in patients with polycystic ovary syndrome. 12364442 2002
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.070 AlteredExpression disease LHGDN Elevated plasma ghrelin levels in Prader Willi syndrome. 12091883 2002
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome 		0.030 Biomarker disease LHGDN Ghrelin is no longer able to stimulate growth hormone secretion in patients with Cushing's syndrome but instead induces exaggerated corticotropin and cortisol responses. 12566947 2002
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.030 AlteredExpression disease BEFREE Expression and action of the growth hormone releasing peptide ghrelin and its receptor in prostate cancer cell lines. 11874717 2002
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.020 AlteredExpression disease BEFREE Expression and action of the growth hormone releasing peptide ghrelin and its receptor in prostate cancer cell lines. 11874717 2002
CUI: C0006625
Disease: Cachexia
Cachexia 		0.310 AlteredExpression phenotype LHGDN Increased plasma ghrelin level in lung cancer cachexia. 12576449 2003
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.100 GeneticVariation disease BEFREE Preproghrelin Leu72Met polymorphism in patients with type 2 diabetes mellitus. 12974878 2003
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.070 AlteredExpression disease LHGDN Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome. 12519848 2003
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		0.050 Biomarker disease LHGDN Balance in ghrelin and leptin plasma levels in anorexia nervosa patients and constitutionally thin women. 12519838 2003
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		0.050 AlteredExpression disease LHGDN Fasting plasma ghrelin levels in subtypes of anorexia nervosa. 12892652 2003
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		0.050 Biomarker disease LHGDN Loss of meal-induced decrease in plasma ghrelin levels in patients with anorexia nervosa. 12679456 2003
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.020 Biomarker group LHGDN Acute plasma glucose increase, but not early insulin response, regulates plasma ghrelin. 14585085 2003
CUI: C0001206
Disease: Acromegaly
Acromegaly 		0.010 AlteredExpression disease LHGDN Serum ghrelin levels in acromegaly: effects of surgical and long-acting octreotide therapy. 12727951 2003
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.010 GeneticVariation group BEFREE The Leu72Met polymorphism of the preproghrelin gene was not related to cardiovascular disease in type 2 diabetes mellitus patients. 12974878 2003
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.010 AlteredExpression disease LHGDN Low ghrelin concentrations in nonalcoholic fatty liver disease are related to insulin resistance. 14671152 2003