GHRL, ghrelin and obestatin prepropeptide, 51738

N. diseases: 183; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.010 Biomarker group LHGDN Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes. 14514639 2003
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.010 AlteredExpression group LHGDN Increased plasma ghrelin level in lung cancer cachexia. 12576449 2003
CUI: C0030305
Disease: Pancreatitis
Pancreatitis 		0.010 Biomarker disease BEFREE (1) Administration of ghrelin attenuates pancreatic damage in caerulein-induced pancreatitis; (2) Protective effect of ghrelin administration seems Background: Ghrelin, a circulating growth hormone-releasing peptide isolated from human and rat stomach, stimulates growth hormone secretion, food intake and exhibits gastroprotective properties. 14726611 2003
CUI: C0041948
Disease: Uremia
Uremia 		0.010 Biomarker disease LHGDN Leptin, ghrelin, and proinflammatory cytokines: compounds with nutritional impact in chronic kidney disease? 14681862 2003
CUI: C0334299
Disease: Carcinoid tumor no ICD-O subtype
Carcinoid tumor no ICD-O subtype 		0.010 AlteredExpression phenotype BEFREE Cyclical Cushing's syndrome in a patient with a bronchial neuroendocrine tumor (typical carcinoid) expressing ghrelin and growth hormone secretagogue receptors. 14671177 2003
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.010 GeneticVariation group BEFREE The association between the Leu72Met polymorphism of the preproghrelin gene and diabetic complications was examined in patients with type 2 diabetes mellitus. 12974878 2003
CUI: C0342444
Disease: Cyclical Cushing's syndrome
Cyclical Cushing's syndrome 		0.010 Biomarker disease BEFREE Cyclical Cushing's syndrome in a patient with a bronchial neuroendocrine tumor (typical carcinoid) expressing ghrelin and growth hormone secretagogue receptors. 14671177 2003
CUI: C1334452
Disease: Neuroendocrine neoplasm of lung
Neuroendocrine neoplasm of lung 		0.010 Biomarker disease BEFREE Cyclical Cushing's syndrome in a patient with a bronchial neuroendocrine tumor (typical carcinoid) expressing ghrelin and growth hormone secretagogue receptors. 14671177 2003
CUI: C0038358
Disease: Gastric ulcer
Gastric ulcer 		0.300 Therapeutic disease CTD_human Exogenous and endogenous ghrelin in gastroprotection against stress-induced gastric damage. 15177919 2004
CUI: C0243026
Disease: Sepsis
Sepsis 		0.200 Biomarker disease RGD Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsis. 15155262 2004
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.100 Biomarker disease LHGDN Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus. 15538935 2004
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome 		0.070 AlteredExpression disease LHGDN Elevated ghrelin plasma levels in patients with polycystic ovary syndrome. 15057670 2004
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.070 Biomarker disease LHGDN Elevated fasting plasma ghrelin in prader-willi syndrome adults is not solely explained by their reduced visceral adiposity and insulin resistance. 15070936 2004
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.070 Biomarker disease LHGDN Hyperghrelinemia is a common feature of Prader-Willi syndrome and pituitary stalk interruption: a pathophysiological hypothesis. 15192277 2004
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.070 Biomarker disease LHGDN Correlation between fasting plasma ghrelin levels and age, body mass index (BMI), BMI percentiles, and 24-hour plasma ghrelin profiles in Prader-Willi syndrome. 15292322 2004
CUI: C0003123
Disease: Anorexia
Anorexia 		0.040 Biomarker disease LHGDN [Role of ghrelin in the pathophysiology of eating behaviour]. 15382608 2004
CUI: C0003123
Disease: Anorexia
Anorexia 		0.040 Biomarker disease LHGDN Plasma ghrelin concentrations, food intake, and anorexia in liver failure. 15126531 2004
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.040 Biomarker disease LHGDN Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells. 15117840 2004
CUI: C0006370
Disease: Bulimia
Bulimia 		0.030 Biomarker disease LHGDN [Role of ghrelin in the pathophysiology of eating behaviour]. 15382608 2004
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome 		0.030 AlteredExpression disease LHGDN Endogenous and exogenous glucocorticoids decrease plasma ghrelin in humans. 15248830 2004
CUI: C0221406
Disease: Pituitary-dependent Cushing's disease
Pituitary-dependent Cushing's disease 		0.030 AlteredExpression disease LHGDN Endogenous and exogenous glucocorticoids decrease plasma ghrelin in humans. 15248830 2004
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.030 Biomarker disease BEFREE Ghrelin, a natural growth hormone secretagogue (GHS), has been identified in prostate carcinoma cell lines. 14763915 2004
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.020 Biomarker disease LHGDN Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus. 15538935 2004
CUI: C0162429
Disease: Malnutrition
Malnutrition 		0.020 Biomarker disease LHGDN Plasma ghrelin concentrations, food intake, and anorexia in liver failure. 15126531 2004
CUI: C0162429
Disease: Malnutrition
Malnutrition 		0.020 AlteredExpression disease LHGDN Effects of estrogen and recombinant human insulin-like growth factor-I on ghrelin secretion in severe undernutrition. 15292338 2004