|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
High ARID4B expression was strongly correlated with tumor number (P = .02), vascular invasion (P = .004), Edmondson-Steiner grades (P = .000), and tumor-node-metastasis stages (P = .001).
|
29288040 |
2018 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
In conclusion, our results indicated that ARID4A and ARID4B may serve as tumor suppressor in PCa progression, suggesting that they might be the potential therapeutic targets in prostate cancer.
|
29797600 |
2018 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Therefore, ARID4B is a satisfactory biomarker to highlight tumour component and predict tumour behaviour in primary brain neoplasms.
|
27451434 |
2017 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Importantly, 10% of the CCGs are involved in chromatin remodeling, including Arid4b, Kdm6a, and Nsd3, and all SB tumors have at least one mutated gene involved in this process; 20 CCGs, including Ctnnd1, Fbxo11, and Vgll4, are also significantly associated with poor patient survival.
|
22421440 |
2012 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Consistent with our genetic analysis and in vivo experiments in our mouse model system, ARID4B expression was also an independent predictor of distant metastasis-free survival in breast cancer patients with ER+ tumors.
|
22693453 |
2012 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
The two potential markers brcaa1 and ndr1 identified may be used to distinguish cancer status fand non-cancer status.
|
15761963 |
2005 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
RBP1L1 appears to be a molecular marker associated with a broad range of human malignancies.
|
11481388 |
2001 |
|
Diabetes
|
0.030 |
Biomarker
|
disease |
BEFREE |
This article reveals the mechanism of BCAA-induced insulin resistance and the relationship between exercise and BCAAs metabolism, adds a guarantee for the use of BCAAs, and provides a new explanation for the occurrence of diabetes and how exercise improves diabetes.
|
31666474 |
2019 |
|
Diabetes Mellitus
|
0.030 |
Biomarker
|
group |
BEFREE |
This article reveals the mechanism of BCAA-induced insulin resistance and the relationship between exercise and BCAAs metabolism, adds a guarantee for the use of BCAAs, and provides a new explanation for the occurrence of diabetes and how exercise improves diabetes.
|
31666474 |
2019 |
|
Diabetes
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
BCAA levels were increased in the blood in human patients and mice with diabetes or AD.
|
29802157 |
2018 |
|
Diabetes Mellitus
|
0.030 |
AlteredExpression
|
group |
BEFREE |
BCAA levels were increased in the blood in human patients and mice with diabetes or AD.
|
29802157 |
2018 |
|
Obesity
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Decreased BCKD activity is the main cause of increased BCAA levels and BCKAs in maple syrup urine disease, and plays a role in increased BCAA levels in diabetes type 2 and obesity.
|
29755574 |
2018 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, the knockout expression of ARID4A and ARID4B promoted PCa cell proliferation, migration and invasion in vitro.
|
29797600 |
2018 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
High ARID4B expression was strongly correlated with tumor number (P = .02), vascular invasion (P = .004), Edmondson-Steiner grades (P = .000), and tumor-node-metastasis stages (P = .001).
|
29288040 |
2018 |
|
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
In this study, we used data from The Cancer Genome Atlas and Gene Expression Omnibus to analyze ARID4B expression in HCC.
|
29288040 |
2018 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Although ARID4B is known to promote tumour metastasis in breast cancer and inhibit transformation and progression in leukaemia, the possible effect of ARID4B on primary brain tumours (PBTs) is not well characterised.
|
27451434 |
2017 |
|
Obesity
|
0.030 |
Biomarker
|
disease |
BEFREE |
In contrast, no associations were observed between circulating BCAAs (that is, Val, Leu, Ile), measures of obesity and insulin resistance.
|
28378845 |
2017 |
|
Diabetes
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our aims were to evaluate the relationship between BCAA and IR as well as later diabetes risk and explore the phenotypic and genetic factors influencing BCAA level based on available studies.
|
27642608 |
2016 |
|
Diabetes Mellitus
|
0.030 |
Biomarker
|
group |
BEFREE |
Our aims were to evaluate the relationship between BCAA and IR as well as later diabetes risk and explore the phenotypic and genetic factors influencing BCAA level based on available studies.
|
27642608 |
2016 |
|
Neoplasm Metastasis
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
Inherited variation in miR-290 expression suppresses breast cancer progression by targeting the metastasis susceptibility gene Arid4b.
|
23447578 |
2013 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
ARID4B physically interacts with the breast cancer metastasis suppressor BRMS1, and we detected differential binding of the Arid4b alleles to histone deacetylase complex members mSIN3A and mSDS3, suggesting that the mechanism of Arid4b action likely involves interactions with chromatin modifying complexes.
|
22693453 |
2012 |
|
Obesity
|
0.030 |
Biomarker
|
disease |
BEFREE |
Furthermore, the ratio of branched-chain amino acid to aromatic amino acid concentrations (BCAA/AAA) in PCOS plasma was significantly reduced in PCOS patients and was insusceptible to obesity and insulin sensitivity.
|
23198915 |
2012 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Ectopic expression of Arid4b promoted primary tumor growth in vivo as well as increased migration and invasion in vitro, and the phenotype was associated with polymorphisms identified between the AKR/J and DBA/2J alleles as predicted by our genetic analyses.
|
22693453 |
2012 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Importantly, 10% of the CCGs are involved in chromatin remodeling, including Arid4b, Kdm6a, and Nsd3, and all SB tumors have at least one mutated gene involved in this process; 20 CCGs, including Ctnnd1, Fbxo11, and Vgll4, are also significantly associated with poor patient survival.
|
22421440 |
2012 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
The two potential markers brcaa1 and ndr1 identified may be used to distinguish cancer status fand non-cancer status.
|
15761963 |
2005 |