PENK, proenkephalin, 5179

N. diseases: 124; N. variants: 5
Disease: Opioid withdrawal ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029104
Disease: Opioid withdrawal
Opioid withdrawal 		0.010 AlteredExpression disease BEFREE Preproenkephalin (PPE) mRNA in the caudal periaqueductal gray (cPAG), an important brain region in opioid withdrawal, is increased by both opioid antagonist (naloxone)-precipitated and spontaneous morphine withdrawal, but not by various other stresses in rats, indicating a role of endogenous enkephalins in the cPAG in morphine withdrawal. 10887947 2000