|
Liver carcinoma
|
0.470 |
GeneticVariation
|
disease |
GWASCAT |
Genome-Wide Association Study Identifies a New Locus at 7q21.13 Associated with Hepatitis B Virus-Related Hepatocellular Carcinoma.
|
29246937 |
2018 |
|
Ovarian Mucinous Adenocarcinoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Common Variable Immunodeficiency
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association identifies diverse causes of common variable immunodeficiency.
|
21497890 |
2011 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-Wide Association Study Identifies a New Locus at 7q21.13 Associated with Hepatitis B Virus-Related Hepatocellular Carcinoma.
|
29246937 |
2018 |
|
Leukemia, Myelocytic, Acute
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
|
27903959 |
2017 |
|
ESTRONE MEASUREMENT
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway.
|
28429243 |
2017 |
|
Androstenedione measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway.
|
28429243 |
2017 |
|
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Liver carcinoma
|
0.470 |
Biomarker
|
disease |
BEFREE |
In conclusion, it was implied that LINC00707 can lead to HCC progression through sponging miR-206 and modulating CDK14.
|
30488589 |
2019 |
|
Liver carcinoma
|
0.470 |
Biomarker
|
disease |
BEFREE |
Quantitative reverse transcription (RT)-PCR evaluation further indicated upregulation of a single candidate gene, PFTK1, that correlated significantly with both advanced metastatic HCCs (P = 0.032) and tumor microvascular invasion (P = 0.012).
|
17559150 |
2007 |
|
Liver carcinoma
|
0.470 |
Biomarker
|
disease |
BEFREE |
MiR-877-5p suppresses cell growth, migration and invasion by targeting cyclin dependent kinase 14 and predicts prognosis in hepatocellular carcinoma.
|
29863248 |
2018 |
|
Liver carcinoma
|
0.470 |
Biomarker
|
disease |
CTD_human |
The results suggest that seven of these genes, including VCAM1 and CDK14, may confer growth and infiltration capacity to HCC cells.
|
22922871 |
2012 |
|
Liver carcinoma
|
0.470 |
Biomarker
|
disease |
BEFREE |
Our study stemmed from an earlier investigation where we demonstrated that PFTK1 kinase conferred cell migratory advantages in human hepatocellular carcinoma (HCC) cells.
|
21184254 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we showed from tissue microarray that common upregulations of PFTK1 in primary HCC tumors (n=133/180) correlated significantly with early age onset (40 years), advance tumor grading and presence of microvascular invasion (P0.05).
|
21577206 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PFTK1 is a member of cyclin-dependent kinases (Cdks) family and has been reported to contribute to tumor migration and invasion.
|
26234562 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Knockdown of PFTK1 inhibits tumor cell proliferation, invasion and epithelial-to-mesenchymal transition in pancreatic cancer.
|
26823712 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Quantitative reverse transcription (RT)-PCR evaluation further indicated upregulation of a single candidate gene, PFTK1, that correlated significantly with both advanced metastatic HCCs (P = 0.032) and tumor microvascular invasion (P = 0.012).
|
17559150 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, knockdown of E2F5 and PFTK1 mimicked the tumor-suppressive effects of miR-1-3p overexpression on PCa progression.
|
30185212 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Upregulated PFTK1 promotes tumor cell proliferation, migration, and invasion in breast cancer.
|
26033031 |
2015 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Through Cell Counting Kit (CCK)-8 assay, flow cytometry, colony formation, wound healing and transwell assays, the vitro studies demonstrated that PFTK1 overexpression promoted proliferation, migration and invasion of gastric cancer cells, while PFTK1 knockdown led to the opposite results.
|
26488471 |
2015 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
MiR-877-5p suppresses cell growth, migration and invasion by targeting cyclin dependent kinase 14 and predicts prognosis in hepatocellular carcinoma.
|
29863248 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Overexpression of miR-216a significantly suppressed cell proliferation, migration and invasion in vivo and in vitro by inhibiting CDK14 production.
|
29022909 |
2017 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
PFTK1 is a member of cyclin-dependent kinases (Cdks) family and has been reported to contribute to tumor migration and invasion.
|
26234562 |
2015 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Taken together, these results suggest that knockdown of PFTK1 inhibited the proliferation and invasion of colon cancer cells as well as the EMT progress by suppressing the Sonic hedgehog signaling pathway.
|
27458094 |
2016 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In summary, the present study has provided further evidence that knockdown of PFTK1 inhibited the proliferation and invasion of pancreatic cancer cells as well as the EMT progress by suppressing the PI3K/Akt signaling pathway.
|
26823712 |
2015 |