|
Esophagitis
|
0.300 |
Biomarker
|
disease |
CTD_human |
c-Fos immunoreactivity in the brain after esophageal acid stimulation.
|
12928072 |
2003 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Laryngopharyngeal Reflux
|
0.030 |
Biomarker
|
disease |
BEFREE |
These results suggest that LPR may play a role in the development of CRS through pepsin A reflux, and increased HSP70 expression may be associated with the pathogenic mechanism of mucosal injury in CRS.
|
28784015 |
2017 |
|
Laryngopharyngeal Reflux
|
0.030 |
Biomarker
|
disease |
BEFREE |
Is Pepsin a Reliable Marker of Laryngopharyngeal Reflux? A Systematic Review.
|
28585488 |
2017 |
|
Laryngopharyngeal Reflux
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Although pepsin, a component of LPR, has been associated with inflammatory diseases of the aerodigestive tract, its presence in the airways of laryngomalacia patients is unknown.
|
28224634 |
2017 |
|
Lung Diseases, Interstitial
|
0.010 |
Biomarker
|
group |
BEFREE |
We measured pepsin, a marker of gastric aspiration, in bronchoalveolar lavage (BAL) fluid of chronic fibrosing ILD patients to evaluate the association between BAL fluid pepsin and prognosis of chronic fibrosing ILDs.
|
30405002 |
2018 |
|
Craniosynostosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that LPR may play a role in the development of CRS through pepsin A reflux, and increased HSP70 expression may be associated with the pathogenic mechanism of mucosal injury in CRS.
|
28784015 |
2017 |
|
Nasal Polyps
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Pepsin A levels in nasal secretions were significantly higher in CRSwNP/CRSsNP patients than in controls.
|
28784015 |
2017 |
|
Chronic sinusitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We investigated the relationship between laryngopharyngeal reflux (LPR) and chronic rhinosinusitis (CRS), and explored the effects of pepsin A on the level of heat shock protein 70 (HSP70) in CRS.
|
28784015 |
2017 |
|
Hemorrhagic colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Functional analysis showed that EspP is a protease capable of cleaving pepsin A and human coagulation factor V. Degradation of factor V could contribute to the mucosal haemorrhage observed in patients with haemorrhagic colitis.
|
9194704 |
1997 |
|
Ulcerative Colitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
It was recently reported that, using a T-cell receptor alpha-chain complementary deoxyribonucleic acid probe (pGA5) and the restriction enzyme Eco RV, a 10-kilobase restriction fragment length polymorphism was detected significantly more frequently in patients with ulcerative colitis than in patients with Crohn's disease and controls.
|
2571544 |
1989 |
|
Crohn Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
It was recently reported that, using a T-cell receptor alpha-chain complementary deoxyribonucleic acid probe (pGA5) and the restriction enzyme Eco RV, a 10-kilobase restriction fragment length polymorphism was detected significantly more frequently in patients with ulcerative colitis than in patients with Crohn's disease and controls.
|
2571544 |
1989 |
|
Inflammatory Bowel Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Therefore, there is as yet no evidence for an association between polymorphisms of Eco RV-digested genomic DNA probed with the pGA5 T-cell receptor alpha-chain complementary deoxyribonucleic acid and the predisposition to inflammatory bowel disease.
|
2571544 |
1989 |
|
Barrett Epithelium
|
0.010 |
Biomarker
|
disease |
BEFREE |
Discrepancies consisted mainly of a stronger pepsinogen 5 band in the Barrett's epithelium, with a higher incidence in biopsy specimens with features of dysplasia than with no or indefinite dysplasia; the difference was, however, not statistically significant.
|
3305135 |
1987 |