|
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We previously demonstrated the estrogen-like effects of tamoxifen on the acceleration of growth and increased progesterone receptor concentrations of human endometrial carcinomas grown in the nude mouse experimental model.
|
1733196 |
1992 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Selective down-regulation of progesterone receptor isoform B in poorly differentiated human endometrial cancer cells: implications for unopposed estrogen action.
|
9581825 |
1998 |
|
Endometrial Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
p53 overexpression and mutation in endometrial carcinoma: inverted relation with estrogen and progesterone receptor status.
|
10101596 |
1999 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
All translated variant proteins might possess functional diversity and might modify the progestational action of wild-type PR, and the expression of some PR variant mRNAs may be lost as endometrial cancer cells undergo dedifferentiation.
|
10644942 |
2000 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this study, we examine the effects of progesterone on the gene expression of hTERT in breast and endometrial cancer cell lines expressing progesterone receptor.
|
11034074 |
2000 |
|
Endometrial Carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Progesterone receptor B gene inactivation and CpG hypermethylation in human uterine endometrial cancer.
|
11196205 |
2001 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The relative overexpression of estrogen receptor (ER)-alpha exon 5 splicing variant, the disrupted synchronization of ER-beta and ER-alpha expressions, and the suppression of progesterone receptor (PR) form A expression as a transcriptional repressor might be related to metastatic potential of uterine endometrial cancers, leading to poor patient prognosis related to estrogen refractoriness.
|
11282273 |
2000 |
|
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The purpose of these studies was to reestablish high progesterone receptor isoform A and B gene expressions in such endometrial cancer cells and to examine the effects of progestin treatment on cell growth and metastatic potential after this transformation.
|
11303185 |
2001 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
No UIE tumors exhibited MSI, and the tumors in these patients had a higher expression of p53 (p < 0.01), a lower expression of ER (p < 0.05) and PR (p < 0.05), and a higher frequency of DNA aneuploidy (p < 0.01) than the UCE tumors.
|
11603221 |
2001 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Since local tissue degradation is also a feature of malignant tumors, our goal was to analyze the gene expression of interleukin-1alpha and other interleukin-1 family members and compare it with estrogen receptor alpha, estrogen receptor beta, and progesterone receptor mRNA expression in 27 endometrial carcinomas and 13 normal endometria.
|
12051868 |
2002 |
|
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Only one (4.2%) of 24 endocervical carcinomas was positive for both estrogen receptor and progesterone receptor, whereas 18 (75%) of 24 endometrial carcinomas were positive for estrogen receptor and 23 (95.8%) of 24 endometrial carcinomas were positive for progesterone receptor (p <0.001, chi2 test).
|
12170086 |
2002 |
|
Endometrial Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that the +331G/A hPR gene polymorphism may contribute to endometrial cancer risk by increasing expression of the hPR-B isoform.
|
12218173 |
2002 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The results of these experiments suggest that ERalpha-A, ERalpha-B, and PR-A were expressed and ERalpha-C and PR-B were inactivated in endometrial cancers.
|
12770752 |
2003 |
|
Endometrial Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We also investigated whether the expression of estrogen receptors (ERalpha and ERbeta), progesterone receptor, and androgen receptor genes are influenced by the CYP1B1 genotypes in endometrial cancer.
|
12873984 |
2003 |
|
Endometrial Carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Consequences of loss of progesterone receptor expression in development of invasive endometrial cancer.
|
14519645 |
2003 |
|
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, topologic coexpression of both coactivators and ER/PR was lost in endometrial carcinoma.
|
14601091 |
2003 |
|
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of uteroglobin and matrix metalloproteinase-9 genes in endometrial cancer: relationship to estrogen and progesterone receptor status.
|
14719079 |
2004 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Gene expression of SRC-1, SRC-2, SRC-3, N-CoR, SMRT, ERalpha, and PR was measured in 26 samples of normal endometrium and 30 primary endometrial carcinomas using real-time RT-PCR.
|
14751175 |
2004 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Progesterone receptor (PR) mRNA was upregulated in the Ishikawa endometrial cancer cell line.
|
14974442 |
2004 |
|
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Endometrial carcinomas and their metastases were generally positive for ER (86%), PR (93%) and VIM (100%) but rarely positive for CEA (14%) and HPV (0%).
|
15010819 |
2004 |
|
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The measurement of PR isoforms has prognostic value in EC.
|
15099952 |
2004 |
|
Endometrial Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
An application to progesterone-receptor haplotypes and endometrial cancer further illustrates that the performance of all these methods depends on how well the observed haplotypes "tag" the unobserved causal variant.
|
15637718 |
2005 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Future therapeutic regimens targeted at enhancing progesterone receptor expression have the potential to improve outcomes in women with endometrial cancer.
|
15657363 |
2005 |
|
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Epigenetic-mediated upregulation of progesterone receptor B gene in endometrial cancer cell lines.
|
16024066 |
2005 |
|
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The present study was undertaken to evaluate the clinical significance of intratumoral PR isoform status in patients with endometrioid endometrial carcinoma.
|
16999816 |
2006 |