|
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
181 genes were significantly up- or down-regulated with increasing BMI in endometrioid EC (q-value<0.01), including LPL, IRS-1, IGFBP4, IGFBP7 and the progesterone receptor.
|
27288544 |
2016 |
|
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Endometrial carcinomas and their metastases were generally positive for ER (86%), PR (93%) and VIM (100%) but rarely positive for CEA (14%) and HPV (0%).
|
15010819 |
2004 |
|
Endometrial Carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Progesterone receptor B gene inactivation and CpG hypermethylation in human uterine endometrial cancer.
|
11196205 |
2001 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Progesterone receptor (PR) mRNA was upregulated in the Ishikawa endometrial cancer cell line.
|
14974442 |
2004 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A lentiviral-based shRNA knockdown approach was used to generate stable PGRMC1-intact and PGRMC1-deplete Ishikawa endometrial cancer cell lines that also lacked expression of the classical progesterone receptor (PGR).
|
25304370 |
2015 |
|
Endometrial Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Aberrant methylation patterns were observed in the first exon of PR gene, and the methylation density is correlated with the differentiation of different types of endometrial cancer cells.
|
17556066 |
2007 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
AKT is reported to regulate progesterone receptor B dependent transcription and angiogenesis in endometrial cancer.
|
31781484 |
2019 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Akt regulates progesterone receptor B-dependent transcription and angiogenesis in endometrial cancer cells.
|
26996671 |
2016 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
All translated variant proteins might possess functional diversity and might modify the progestational action of wild-type PR, and the expression of some PR variant mRNAs may be lost as endometrial cancer cells undergo dedifferentiation.
|
10644942 |
2000 |
|
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Altered expression of genes involved in progesterone biosynthesis, metabolism and action in endometrial cancer.
|
23200943 |
2013 |
|
Endometrial Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
An application to progesterone-receptor haplotypes and endometrial cancer further illustrates that the performance of all these methods depends on how well the observed haplotypes "tag" the unobserved causal variant.
|
15637718 |
2005 |
|
Endometrial Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of the +331G/A progesterone receptor gene (PgR) polymorphism with risk of endometrial cancer in Caucasian women: a meta-analysis.
|
25037596 |
2015 |
|
Endometrial Carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Chromatin composition alterations and the critical role of MeCP2 for epigenetic silencing of progesterone receptor-B gene in endometrial cancers.
|
24531693 |
2014 |
|
Endometrial Carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Consequences of loss of progesterone receptor expression in development of invasive endometrial cancer.
|
14519645 |
2003 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
CRISPR/Cas9-Mediated Gene Knockout of ARID1A Promotes Primary Progesterone Resistance by Downregulating Progesterone Receptor B in Endometrial Cancer Cells.
|
31072420 |
2019 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
EGFR and progesterone receptor isotype B (PR-B) messenger RNA and protein levels were determined in EC tissue samples and cell lines by immunohistochemical, real-time reverse transcriptase-polymerase chain reaction and Western blot analyses.
|
20564127 |
2010 |
|
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Epigenetic-mediated upregulation of progesterone receptor B gene in endometrial cancer cell lines.
|
16024066 |
2005 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Estrogen receptor (ER), progesterone receptor (PR), and Ki-67 and P53 receptor levels in endometrial curettage material were investigated for their ability to predict lymph node (LN) involvement in patients with endometrioid-type endometrial cancer (EEC).
|
31395281 |
2020 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of estrogen receptor, progesterone receptor (PgR), androgen receptor, and Ki67 index was assessed with residual tissue samples of endometrial cancer.
|
28540420 |
2017 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of seven ERα splice variants, total PR and of five PR transcript isoforms was found to be significantly decreased in endometrial cancer.
|
26428028 |
2015 |
|
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of uteroglobin and matrix metalloproteinase-9 genes in endometrial cancer: relationship to estrogen and progesterone receptor status.
|
14719079 |
2004 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Future therapeutic regimens targeted at enhancing progesterone receptor expression have the potential to improve outcomes in women with endometrial cancer.
|
15657363 |
2005 |
|
Endometrial Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Gene expression of SRC-1, SRC-2, SRC-3, N-CoR, SMRT, ERalpha, and PR was measured in 26 samples of normal endometrium and 30 primary endometrial carcinomas using real-time RT-PCR.
|
14751175 |
2004 |
|
Endometrial Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in LD block 3 of the PGR locus was associated with endometrial cancer risk (P(global test) = 0.002), with haplotypes 3C, 3D and 3F associated with 31-34% increased risk.
|
20547493 |
2010 |
|
Endometrial Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical staining for AR, ER, and PR was performed on an endometrial tissue microarray containing 50 ECA with a variety of morphologic subtypes as well as 20 benign and 9 atypical hyperplastic endometria.
|
28582344 |
2018 |