|
Crohn Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data highlight important and novel findings pertaining to CD-associated changes to the intestinal expression of CYP3A4 and P-gp that are of relevance to better predict substrate drug dosing for patients with CD.
|
31393129 |
2019 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, a recent study reported that multidrug resistance protein 1 (MDR1) regulated effector T-cell function in the ileum from bile acid-driven oxidative stress and MDR1 loss of function in a subset of patients with Crohn's disease.
|
30402511 |
2018 |
|
Crohn Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our aim was to elucidate the activity of CYP3A4 and P-gp in subjects with Crohn's disease (CD) and to evaluate their influence on budesonide pharmacokinetics.
|
28301431 |
2017 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whereas wild-type Teff cells upregulated Mdr1 in the ileum, those lacking Mdr1 displayed mucosal dysfunction and induced Crohn's disease-like ileitis following transfer into Rag1<sup>-/-</sup> hosts.
|
29262351 |
2017 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the two ABCB1 SNPs may not contribute to CD susceptibility in the populations of Poland and B&H.
|
28759738 |
2017 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, we investigated whether SNPs in MDR1 are associated with CD in Algerian pediatric patients.
|
27603561 |
2016 |
|
Crohn Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results demonstrated that the sustained chronic inflammation could induce the intrinsic resistance presented as P-gp over-expression in PBMC in Crohn's disease through STAT3/Nf-κb pathway and this resistance might be reversed by combinational usage of P-gp inhibitors.
|
26324318 |
2015 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of MDR1 are associated with patient's GC response and a predisposition to CD in Chinese population.
|
25346426 |
2015 |
|
Crohn Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Contrary to the first 2 categories, genes involved in xenobiotic activity, such as ABCB1, had lower expression in the pouchitis and Crohn's disease-like groups compared with the no pouchitis and familial adenomatous polyposis groups.
|
24874456 |
2014 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Besides, stratified analysis by clinical type also indicated that no significant association between MDR1 C3435T and the risk of Crohn's disease and ulcerative colitis was observed.
|
24449364 |
2014 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MDR1 polymorphisms are associated with both CD and UC with a stronger association with UC.
|
23537364 |
2013 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expression level of the ABCB1/MDR1 gene which encodes P-glycoprotein seems to be of great prognostic relevance while evaluating patients' susceptibility to UC or CD.
|
22661185 |
2012 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined whether DNA variation in the ABCB1 gene was associated with CS dependency in children with CD.
|
21987299 |
2011 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The polymorphism located in intron 3 of the MDR1 gene showed a weak association with CD, and a marginally suggestive association with UC.
|
18819034 |
2009 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether DNA variants in the MDR1 gene were associated with susceptibility for CD and specific phenotypes in children.
|
19107781 |
2009 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MDR1 polymorphisms and response to azathioprine therapy in patients with Crohn's disease.
|
17262810 |
2007 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three hundred eighty-eight German IBD patients [244 with Crohn's disease (CD), 144 with ulcerative colitis (UC)] and 1,005 German healthy controls were genotyped for the two MDR1 SNPs on positions 2677G>T/A and 3435C>T.
|
17665184 |
2007 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In our pediatric cohort, the promoter -308A polymorphism of TNF-alpha but not the MDR1 gene is significantly involved in the predisposition to both CD and UC.
|
17255827 |
2007 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A significant association was found between the MDR1 C3435T polymorphism and patients with ileo-colonic CD (OR = 3.34; 95% CI: 1.34-8.27).
|
17260353 |
2007 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Therefore, considering our results and those from others, the MDR1 gene behaves as a common risk factor for both CD and UC.
|
16374256 |
2006 |
|
Crohn Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We compared CYP3A and P-gp mRNA expression in 19 noninflamed duodenal biopsies from children with CD with 19 normal biopsies.
|
16917230 |
2006 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, considering our results and those from others, the MDR1 gene behaves as a common risk factor for both CD and UC.
|
16374256 |
2006 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
This 'candidate gene' approach provides compelling evidence to support the contribution of the ABCB1/MDR1 gene in determining risk to UC but not to CD and provides new insights into the localization of the critical susceptibility determinants within the gene.
|
16434479 |
2006 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls).
|
15685540 |
2005 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Two polymorphisms (C3435T and G2677T/A) of the multidrug resistance 1 gene have been correlated with the altered P-glycoprotein expression and function in humans, and associated with predisposition to ulcerative colitis and Crohn's disease.
|
16305727 |
2005 |