|
Drug Resistant Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taking together, these data suggest that stimulation of EPO depending signaling system could not only play a central role in brain cell protection, but this system could be a new tool for reverse the pharmacoresistant phenotype in refractory epilepsy as well as in other pharmacoresistant hypoxic brain diseases expressing P-gp.
|
31379495 |
2019 |
|
Drug Resistant Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data suggested that overexpression of P-gp and CYP3A during seizures and treated with CBZ may be regulated by PXR or NF-κB p65 activity and expression, which revealed a mechanism underlying the development of DRE.
|
30312753 |
2019 |
|
Drug Resistant Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Neuroinflammation due to high levels of glutamate has been identified as one of the causes of P-gp upregulation, and several studies in animal models of epilepsy suggest that antiinflammatory drugs might prevent P-gp overexpression and, thus, avoid the development of refractory epilepsy.
|
31420290 |
2019 |
|
Drug Resistant Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Therefore, activation of the HIF-1α/P-gp pathway is one hypothesis proposed to explain the pathogenesis of refractory epilepsy.
|
31634239 |
2019 |
|
Drug Resistant Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Consequently, RE and SUDEP share a multidrug resistance (MDR) phenotype, which is mainly associated with brain overexpression of ABC-transporters such as P-glycoprotein (P-gp).
|
31706919 |
2019 |
|
Drug Resistant Epilepsy
|
0.100 |
Biomarker
|
disease |
BEFREE |
We aimed to investigate the expression levels of multidrug resistance gene 1 (MDR1), multidrug resistance-associated protein 1 (MRP1) and multidrug resistance P-glycoprotein (P-gp) in peripheral blood of patients with refractory epilepsy.
|
29318116 |
2018 |
|
Drug Resistant Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The overexpression of multidrug transporters, as the P-glycoprotein (P-gp), at the level of the blood-brain barrier of epileptic patients has been suggested as a key mechanism underlying the refractory epilepsy.
|
29389596 |
2018 |
|
Drug Resistant Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, our findings suggest that miR-298 reverses MDR to AEDs by inhibiting P-gp expression, suggesting a potential target for overcoming MDR in refractory epilepsy.
|
30210283 |
2018 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The relationship between the MDR1 C3435T polymorphism and childhood refractory epilepsy needs further validation.
|
28284049 |
2017 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The reported study was designed to explore associations between the MDR1-C3435T gene SNP and the risk of DRE in the Polish population.
|
27534401 |
2017 |
|
Drug Resistant Epilepsy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results revealed that LTG-loaded mPEG-PLA/TPGS mixed micelles enhanced the absorption of LTG at the nasal cavity and reduced the efflux of LTG in the brain, suggesting that the function of TPGS inhibited P-glycoprotein and LTG-loaded mPEG-PLA/TPGS mixed micelles had the potential to overcome refractory epilepsy.
|
29200847 |
2017 |
|
Drug Resistant Epilepsy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression of P-glycoprotein (P-gp) in the brain is an important mechanism involved in drug‑resistant epilepsy (DRE).
|
28627626 |
2017 |
|
Drug Resistant Epilepsy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The effect of verapamil as Pgp inhibitor on DRE requires further evaluation and research.
|
28560774 |
2017 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that ABCB1 C3435T polymorphism, especially TT genotype, plays an important role in refractory epilepsy.
|
28202008 |
2017 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
G2677T/A polymorphism of MDR1 may play a significant role in the development of DRE in the Polish patients.
|
28608314 |
2017 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The TT genotype of ABCB1 rs717620 was also related with an increased risk of drug-resistant epilepsy (OR = 2.64, 95%CI = 1.03-7.13) compared to the CC+CT genotype in the recessive model.
|
27886333 |
2016 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The presented studies analysed the association between C3435T polymorphism of MDR1 gene and the incidence of drug-resistant epilepsy in the population of Polish children.
|
27391700 |
2016 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that ethnicity plays a role in the association between ABCB1 G2677T/A polymorphism and drug-resistant epilepsy.
|
26220385 |
2015 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have attempted to confirm the association between the ABCB1-C3435T polymorphism and drug-resistant epilepsy and produced discordant findings.
|
24794827 |
2014 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The obtained results clearly confirm the lack of a connection between the occurrence of drug-resistant epilepsy and C435T polymorphism of the MDR1 gene irrespective of the definition of drug resistance applied to the patient.
|
25223475 |
2014 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The relationship established in a subset of the Chinese population between the MDR1 C3435T polymorphism and refractory epilepsy will guide epilepsy treatment and development of new AEDs.
|
24953225 |
2014 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Multidrug resistance 1 (MDR1) 3435C/T genotyping in childhood drug-resistant epilepsy.
|
23465586 |
2014 |
|
Drug Resistant Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HIF-1α may have a regulatory effect on MDR1 expression in refractory epilepsy, which is probably consistent with MDR mechanism in tumor.
|
24590840 |
2014 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To assess the association between MDR1 C3435T polymorphism and the response to anticonvulsants in childhood intractable epilepsy, we conducted a systematic review and meta-analysis.
|
24553780 |
2014 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CYP3A5*3 and C3435T MDR1 polymorphisms in prognostication of drug-resistant epilepsy in children and adolescents.
|
23984379 |
2013 |